Was on 25 mg for 10 years for bipolar 1 & it helped tremendously for delusional thinking (mainly paranoia) but I gained 50 lbs. & now have high blood pressure, high cholesterol & diabetes so I have had to get off it & have to deal with all these physical issues as well as the low self-esteem as the result of the weight gain. Wonderful results for the control of the bipolar moods & thinking but bad side effects for me.