I've been on Lamictal for about 12 yrs. (300 mg.--150 a.m/150 p.m). It has been very helpful for me. I haven't had any negative side effects, but my doc did increase the dosage VERY SLOWLY & even after about 5 yrs. I got a rash & called her to check it out. It ended up being a reaction to the sunscreen I was using, but I wanted to be careful!!--Suzy