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Old Apr 01, 2004, 05:38 PM
Ashley0000 Ashley0000 is offline
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Location: Connecticut, USA
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Does anyone know anything about Gabitril and whether or not its helpful for panic attacks, and anxiety and panic disorder?? Please let me know!! My Dr. wants to put me on it, and I'm scared about whether its going to work and what its side effects are!!Gabitril


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Old Apr 01, 2004, 06:04 PM
Butterfly_Faerie's Avatar
Butterfly_Faerie Butterfly_Faerie is offline
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Location: Ontario, Canada
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I thought that this drug was antiepileptics drug treated for seizures?

<blockquote><font size=1>In reply to:</font><hr>

Tiagabine® or Gabitril is one of the newer antiepileptics that I personally have very little experience. It is availabe in tablet form in multiple dosages.

The medication is felt to work by increasing GABA, an inhibitory neurotransmitter, levels. It does not cause any major side effects affecting liver, bone marrow, etc. It does have some limited drug interactions with some of the other antiepileptic medications but does not generally affect other medications. Its most common dose limiting side effect is sedation.

<hr></blockquote>

<blockquote><font size=1>In reply to:</font><hr>

Low Dose Tiagabine Effectiveness in Anxiety Disorders
Objective: Gamma-aminobutyric acid (GABA), the predominant inhibitory neurotransmitter of the CNS, is involved in the pathophysiology of a wide variety of disorders including anxiety. Tiagabine hydrochloride acts as a selective GABA reuptake inhibitor (SGRI).

Method: Consecutive patients were offered tiagabine in 1 mg incremental doses for the treatment of anxiety, primarily generalized anxiety disorder. Individuals failing anxiety treatment with benzodiazapines, selective serotonin reuptake inhibitors, buspirone and/or with a strong family or personal history of substance abuse were allowed trials.

Results: The SGRI tiagabine improved anxiety and was well tolerated by adult patients with generalized anxiety and one with anxiety secondary to acute antidepressant withdrawal. One disinhibition treatment failure is also discussed.

Conclusions: In acute anxiety treatment, very low initial dosing with gradual increases may be sufficient for anxiety effects, when compared to the higher doses of tiagabine used in epilepsy treatment. Tiagabine may be useful in the treatment of generalized anxiety.

INTRODUCTION
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter of the CNS. Alterations in the GABA system are known to be involved in the pathophysiology of a wide variety of disorders including anxiety.1-4 Agents that enhance GABA neurotransmission have been used in the treatment of anxiety.5-7 Tiagabine hydrochloride increases synaptic GABA availability by blocking the reuptake of GABA via transporter inhibition, thus acting as a selective GABA reuptake inhibitor (SGRI). Tiagabine has shown promise in the treatment of generalized anxiety disorder (GAD),8 posttraumatic stress disorder,9 panic disorder,10 and as monotherapy or augmentation therapy for patients with anxiety disorders who are partial responders.11,12

CASE REPORTS
Of the 5 patients, 4 had GAD and 1 had significant anxiety comorbid with major depressive disorder (MDD). All patients were referrals from primary care and consented to treatment with tiagabine.

<hr></blockquote>

I've never heard of this medication before, I'd look into it or get your doctor to show you information, I've not taken certain anxiety meds because of some side effects that I did not want. Just ask him/her to show you a phamplet on this.

Good luck. I hope this helps.

Here is the website I got this information off of.. ( the second quote)

http://www.personalconsult.com/artic...ctiveness.html

<font color=red>~Sundance~</font color=red>

<font color=blue>"Never react emotionally to criticism. Analyze yourself to determine whether it is justified. If it is, correct yourself. Otherwise, go on about your business."</font color=blue>

<font color=black>Norman Vincent Peale</font color=black>
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