[ComfortablyNumb5]

I can't ignore this very huge elephant in the room anymore. I've lost track of time with my depression and inability to feel pleasure. Absolutely nothing can crack a smile on my face anymore yet I'm scared of an AD because I'm sensitive to dysphoria. Just recently pdoc gave me wellbutrin again and within two weeks I was agitated, angry, anxious ect. However years ago I was on it with no problem. It's like as the years go by, it requires more meds to keep me stable and my BP is only getting worst.

I know we're not pdocs here but maybe someone has some advice or similar experience??? Also I've tried lexapro in the past without an issue as well. But I'm so scared of mania because I get dysphoric and when I get like that it's downright scary.


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[boogiesmash]

I was on Wellbutrin for about a year. My anxiety was high and I was sometimes easily agitated. Now I'm just on cymbalta (also Latuda which doc says helps bipolar depression). I've felt more stable less irritable and doing more things that I like.

[Crazy Hitch]

Cymbalta has been a lifesaver for me. But we don't all react the same. In having said that, I can't recommend it highly enough (if your pdoc agrees of course)

Ask for a c450 test. It uses your genetic information to see which AD works best for you. Citralopam is mild and often used to start people on. Good luck!

[Icare dixit]

I would wait until the longer-term effects of asenapine (Saphris; for you) are known.

Impatience, though understandable, is never wise. Assessing med efficacy takes time and tuning. The more meds, the longer the time needed to really know the efficacy and for tuning. The dose and type of release matters more than the exact substance, sometimes.

Anxiety is a common side-effect of asenapine.

I would suggest you try a psychostimulant first: quite some coffee and black tea (not too much tea)—together with your antipsychotic. That way, you won't "float", but stay focused. At first this may make moods more erratic, but it also forces you and helps in "experimenting" with ways to cope, in a controlled fashion.

An/the atypical antipsychotic should help you with depression, but it is also about waiting/patience, not fighting it too much, acceptance, and other non-medicinal things.

Why did you stop taking quetiapine (again; I forgot)?

[Icare dixit]

And what dose of Saphris do you take now (you mentioned it somewhere, but very bad memory)?

Your quetiapine dosage was really high: the equivalent for asenapine would be something like 25 mg.

[ComfortablyNumb5]

I quit Seroquel because it was taking a lot to make me sleep...and that was IF it even worked. I take 10mg saphris at night now.

Forgot to mention I was also on paxil in the past with no issues.

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[zijax]

I was on wellbutrin for a year. I quit smoking on it but I had severe anxiety. I was hospitalized several timesfor suicide attempts on it.. I also had major addiction and alcohol problems, ( I am clean and sober now 6 months,) and have been off wellbutrin and all AD's for six months. I have BP1 and my pdoc won't put me on AD's anymore.

[lilypup]

I don't mean to be negative here but I am 56 and have also found the BP to be getting worse I have gotten older. The depression part. It does take a constant change of meds to keep me stable.
I don't want to scare you, just wanted you to know.

[ComfortablyNumb5]

Zijax- wow that's crazy. Wellbutrin makes me very dysphoric within two weeks and I've given it many attempts. I've tried to stay away from ADs for awhile now but my anhedonia is getting to be unbearable. I'm the biggest downer lately and I notice I make everyone around me miserable too now. Congrats on the sobriety that's great! Keep up the good work. Wish I could give myself such credit

Lily pup- thank you for your honesty. Negative or not, it needs to be brought up. Years ago I could be stable on just one med and now it takes a whole pharmacy. I don't know whether to blame pdocs, myself, or the illness alone. I'm not even 30 so I don't even want to imagine where I'll be in five years. I often think they'll just throw away the key on me eventually.

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[pirilin]

Remeron.

[zijax]

Thanks Rx