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#1
Dec 03, 2016, 02:36 PM
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Hello, I'm new to posting bug have been following for some time. I was just curious if anyone else has had the genetic testing done to see which meds they metabolize better. I just got my results yesterday and was quite surprised. I was also wondering if anyone is taking Saphris or Invega (Palperidone) and your experiences. Thanks 😊
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 lolitalempika8
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#2
Dec 03, 2016, 02:46 PM
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I've never done genetic testing. But invega has changed my life. I've been on it for two and a half years and I haven't had a manic or mixed episode since. I was cycling pretty rapidly, every two weeks or so, and dealing with mania and psychosis. It was debilitating. Now on invega I have none of that.
The only thing is it has raised my prolactin, which means I stopped having a period and I can't get pregnant. The raised prolactin (along with poor diet of course) has also caused me to gain a lot of weight. Before my prolactin got so high I didn't gain any weight though so it's not really the invega that caused the weight gain. I get the shot every month. It doesn't do anything for my depression though so I take an antidepressant as well.
__________________
Of course it is happening inside your head. But why on earth should that mean that it is not real? -Albus Dumbledore That’s life. If nothing else, that is life. It’s real. Sometimes it f—-ing hurts. But it’s sort of all we have. -Garden State |
| still_crazy
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#3
Dec 03, 2016, 04:12 PM
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Quote:
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#4
Dec 03, 2016, 04:17 PM
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I had genetic testing but Invega was ruled out because I had bad side effects with Risperdal (which acts similar). I haven't tried Saphris yet. Hope I don't need to; Latuda seems to be working well for me.
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#5
Dec 03, 2016, 07:52 PM
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I had the genetic testing done with my pdoc, results were interesting. It wasn't just psych meds that were learned about, I am a rapid metabolizer on some things, a slow metabolizer on others and in some cases I don't process the item at all (folic acid, I have to take the methylated form)..I have to watch out for warfarin and coumadin, and ibuprofen acts as if it is increased in my body (200mg = 250mg). I have a card I carry in my wallet to inform physicians if need be.
I have taken Saphris and was successful with it. I have taken Seroquel and Latuda but have had greater success with saphris |
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#6
Dec 03, 2016, 10:40 PM
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Quote:
Do you know your homocysteine blood/plasma concentration before (and after) you took the supplement(s)? Edit: The obvious question: how much do you take (daily)? Do you know the gene responsible? Is it the methylenetetrahydrofolate reductase (MTHFR) gene? Do you know its genotype?
__________________
Mania kills cells. Brain cells die. Memories become more reduced conceptually, making more efficient use of limited means. Memories shape our reality. Our memories are more or less split in two by abstractions, conceptual reductions. Mood states with memories, concepts, attached. Memories of pain and those of joy. It causes instability, changeability. Fearing that will leave an emptiness between pain and joy and a greater divide. See Me, Feel Me, Touch Me, Heal Me. Last edited by Icare dixit; Dec 03, 2016 at 10:58 PM. |
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#7
Dec 04, 2016, 09:26 AM
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I read that the genetic testing is a good idea, but many Drs don't know much about reading the results
__________________
 Bipolar 1Day Vraylar 3 mg. Wellbutrin 150 Night meds Temazepam 30 mg or lorazepam Hasn't helped yet. From sunny California! |
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#8
Dec 11, 2016, 04:17 AM
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Quote:
as an aside, my pdoc prescribes me a medical grade fish oil called Vayarin for my ADD, and when I came to her to talk about NAC ( I can't remember all the words that stands for), it's an amino acid, she thought that was a good idea and gave me guidance on how much to take. I had read of studies of NAC for people with schizophrenia and bipolar and it was found to be effective in helping with stability. I am unable to take stimulants for add...wellbutrin pushed me into mania as well...stattera did nothing. honestly, I still have some issues but not going to risk mania...I can deal with the add. |
| Icare dixit
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#9
Dec 11, 2016, 09:12 AM
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NAC (N-acetylcysteine) will help you to protect your cells. Since homocysteine is very toxic, that's a good thing (it isn't necessarily always).
I do mean the number/letter combination, like 677TT, for example.
__________________
Mania kills cells. Brain cells die. Memories become more reduced conceptually, making more efficient use of limited means. Memories shape our reality. Our memories are more or less split in two by abstractions, conceptual reductions. Mood states with memories, concepts, attached. Memories of pain and those of joy. It causes instability, changeability. Fearing that will leave an emptiness between pain and joy and a greater divide. See Me, Feel Me, Touch Me, Heal Me. |
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#10
Dec 11, 2016, 02:00 PM
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I have several numbers but these are probably the most important
SLC6A4 poor serotonin transporter SA/SA (this may be why I am able to use some antidepressants with a mood stabilizer (snri's work best) MTHFR poor activity 677CT/1298AC the others of importance are CYP2C19 Rapid metabolizer *1/*17 CYP2C9 Intermediate metab...*1/*2 VKORC1 intermediate sensitivity to warfarin-1639GA what I have been told is that the med level of ibuprofen and warfarin metabolize as a higher dose than what I actually take into my body. not sure about the third one. definitely a good thing to know when it comes to the warfarin! just in case I ever have to take it. does this help? my dr office has the printout copied into my medical records, not that they ever read any of that crap! |
| Icare dixit
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#11
Dec 11, 2016, 04:10 PM
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Yes, certainly. Especially the serotonin transporter is interesting. But a poor serotonin transporter would mean you don't need a med that inhibits the transporter since it's working poorly already. But an SNRI would indeed be better than an SSRI.
I'd suggest supplementation with tryptophan or 5-H-tryptophan (5-HTP). You need more serotonin than most. And it could indeed explain why an SNRI/SSRI has less effect and thus can be used.
__________________
Mania kills cells. Brain cells die. Memories become more reduced conceptually, making more efficient use of limited means. Memories shape our reality. Our memories are more or less split in two by abstractions, conceptual reductions. Mood states with memories, concepts, attached. Memories of pain and those of joy. It causes instability, changeability. Fearing that will leave an emptiness between pain and joy and a greater divide. See Me, Feel Me, Touch Me, Heal Me. |
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#12
Dec 11, 2016, 04:21 PM
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Faster liver metabolism can be a problem. Less of a substance is left, so you need more. That's why those fast metabolisms are a problem.
__________________
Mania kills cells. Brain cells die. Memories become more reduced conceptually, making more efficient use of limited means. Memories shape our reality. Our memories are more or less split in two by abstractions, conceptual reductions. Mood states with memories, concepts, attached. Memories of pain and those of joy. It causes instability, changeability. Fearing that will leave an emptiness between pain and joy and a greater divide. See Me, Feel Me, Touch Me, Heal Me. |
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#13
Dec 11, 2016, 11:17 PM
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thank you so much for the information, my pdoc is pretty good but she didn't explain things nearly as well as you just did
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 Icare dixit
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This is an old thread. You probably should not post your reply to it, as the original poster is unlikely to see it.|
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