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Old Sep 14, 2023, 06:09 AM
insideoutsider's Avatar
insideoutsider insideoutsider is offline
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Do all antipsychotics have an effect on dopamine?

Are there any that do not?

I'm considering going back on vraylar.

But at what point do I need to control my intrusive thoughts as opposed to hide them? Is taking an AP the answer when I haven't had a psychotic episode?

Been sober a full year now - the last thing I want is less pleasure, less boredom.

I'm trying to weight the options. I'm trying to help myself first and foremost, but I'm under constant stress. Constantly butting heads with society. And the last thing I want is to take my self destructive tendencies out on others.

When I was younger under parental supervision I was a great joy to be around. I feel like my fun loving side is gradually fading as I become faced with more and more adult responsibilities.
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Old Sep 14, 2023, 06:19 AM
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MuddyBoots MuddyBoots is offline
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My residential psychiatrist told me the newer antipsychotics don't act on dopamine receptors. I don't know which of the newer antipsychotics she was referring to, but I know Vraylar does act on dopamine receptors.
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  #3  
Old Sep 14, 2023, 03:48 PM
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Brentus Brentus is offline
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Vraylar is unique in that its affinity is for the D3 receptor more than D2. (most typical and atypical anti-psychotics block D2 receptors), but still blocks dopamine. I don't know of any antipsychotic that doesn't work with dopamine to some extent, but I'm no expert.
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Old Sep 14, 2023, 11:52 PM
Tart Cherry Jam Tart Cherry Jam is offline
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I cannot speak intelligently about this but take a look at the newest AP (the link shows dopamine as the search time on the web page)

Pharmacology of CAPLYTA(R) (lumateperone).
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Bipolar I w/psychotic features
Last inpatient stay in 2018

Lybalvi 10 mg
Naltrexone 75 mg


Gabapentin 1500 mg+Vitamin B-complex (against extrapyramidal side effects)

Long-term side effects from medications, some of them discontinued:
- Hypothyroidism
- Obesity BMI ~ 38
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