[Bells129]

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[Blue_Bird]

Do you experience depression or anxiety along with your psychotic disorder? Those would be reasons to add on an AD

[Bells129]

My pdoc thinks I'm depressed.. Thank you

[metamorphosis12]

What antidepressant? and at what dose?. Also, whats your dose of abilify? Because anti-depressants can affect different NT's and regions of the brain. Have you asked him or her why?
Is it an SNRI, SSRI, NARI plus a few that have now come out. That are targeting 5HT7 also. Which is relatively new in the serotonin class, Brintellix!

[metamorphosis12]

Sounds like he wants to hit your 5HT receptors for his diagnosis of depression. That he thinks you have?

[Bells129]

I think they're called or something like that? I don't know the dosage but he said it was quite high. I'm on anti psychotic abilify 30mg. Thank you

[metamorphosis12]

Venlafaxine is Effexor
Venlafaxine - Wikipedia, the free encyclopedia
Effexor is a serotonin-norepinephrine reuptake inhibitor (SNRI) classHave to be careful coming slowly off of that. If that ever happens. Just reports of the side effects but with the norepinephrine inhibitor. It should be a more stimulating drug for most.

The other one I mentioned was vortioxetine- Brintellix
A very new medication that recently came out. It can be quite expensive.
Those two work in different ways.
My pdoc has had good feedback. It's extremely expensive unless you have medicaid or some assistance.Also another in that class is Vilazodone
Both are serotonergic meds. usually used for depression.
I have heard vilazodone can cause more nausea but those are anecdotal reports from the pdoc.

Pharmacology[edit]
Vilazodone acts as a serotonin reuptake inhibitor (IC50 = 2.1 nM; Ki = 0.1 nM) and 5-HT1A receptor partial agonist (IC50 = 0.2 nM; IA = ~60–70%).[6][11] It has negligible affinity for other serotonin receptors such as 5-HT1D, 5-HT2A, and 5-HT2C.[11][12] It also exhibits negligible inhibitory activity at the norepinephrine and dopamine transporters (IC50 = 56 nM for NET and 37 nM for DAT).[1]

Vilazodone - Wikipedia, the free encyclopedia

Vortioxetine is a so-called "serotonin modulator and stimulator".[18] It has been shown to possess the following pharmacological actions:[1][19][20]
Serotonin transporter (SERT) blocker (i.e. serotonin reuptake inhibitor (SRI)) — Ki (binding affinity) = 1.6 nM, IC50 = 5.4 nM
Norepinephrine transporter (NET) blocker — Ki = 113 nM
5-HT1A receptor high-efficacy partial agonist/near-full agonist — Ki = 15 nM, IA = 80%
5-HT1B receptor partial agonist — Ki = 33 nM
5-HT1D receptor antagonist — Ki = 54 nM
5-HT3A receptor antagonist — Ki = 3.7 nM

Vortioxetine also has affinity for the β1-adrenergic receptor (Ki = 46 nM), though any actions at this site are unlikely to contribute to its therapeutic effects and likely only to contribute to side effects.[19]
It has also been shown that vortioxetine increases extracellular levels of acetylcholine and histamine in the rat medial prefrontal cortex following contextual fear conditioning and may be useful in the treatment of Alzheimer's disease.[17]

Vortioxetine - Wikipedia, the free encyclopedia

So far I have heard the best results from vortioxetine. I am actually going to give it a go. As, I do have bouts of depression to varying degrees. It's just so new with the profile. It takes some studying and research as a 5-HT7 antagonist

Current antidepressants still display unsatisfactory efficacy and a delayed onset of therapeutic action. Here we show that the pharmacological blockade of serotonin 7 (5-HT7) receptors produced a faster antidepressant-like response than the commonly prescribed antidepressant fluoxetine. In the rat, the selective 5-HT7 receptor antagonist SB-269970 counteracted the anxiogenic-like effect of fluoxetine in the open field and exerted an antidepressant-like effect in the forced swim test. In vivo, 5-HT7 receptors negatively regulate the firing activity of dorsal raphe 5-HT neurons and become desensitized after long-term administration of fluoxetine. In contrast with fluoxetine, a 1-week treatment with SB-269970 did not alter 5-HT firing activity but desensitized cell body 5-HT autoreceptors, enhanced the hippocampal cell proliferation, and counteracted the depressive-like behavior in olfactory bulbectomized rats. Finally, unlike fluoxetine, early-life administration of SB-269970, did not induce anxious/depressive-like behaviors in adulthood. Together, these findings indicate that the 5-HT7 receptor antagonists may represent a new class of antidepressants with faster therapeutic action.

Neuropsychopharmacology - Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

See what your doc/pdoc says but my personally. Wouldn't touch Effexor with a ten foot pole. Everyone is different though and what works for one.May be a fail for another, obviously

[Bells129]

Thank you!! That's really helpful.

[metamorphosis12]

I'm glad it helped to kind of sort the meds out!