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I know I should ask my pdoc and / or pharmacist this question, but I'm awake and feeling curious in the middle of the night.

I'm on Seroquel (200 mg at nigh) and 50 mg, am and at noon.

There's a warning label on the bottle that says to not eat grapfruits or drink grapefruit juice while on Seroquel.

I also saw in the Mayo clinic drug guide that you shouldn't have grapefruit but it doesn't say why.

So I'm curious, what is it that makes grapefruit a no - no with some psych meds.

Thanks.

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Apparently there is some chemical in grapefruit that interferes with the metabolizing of some medications.

The warning is on my cholesterol pills as well.

It has been known for some time that certain chemicals in grapefruit (known as furanocoumarins) can interfere with the way your body metabolises or processes many medicines in the intestine (gut) or liver before they reach your bloodstream. When this happens, more of a medicine may get into your body, making it work too strongly or causing unwanted side effects.
This happens because of their effect on ‘CYP3A4’ — an enzyme involved in metabolising many medicines. Medicines need to be taken orally (e.g. in the form of a tablet or liquid) to be affected by grapefruit because grapefruit mainly affects this enzyme in the gut.

Mixing grapefruit with medicines | NPS MedicineWise

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Thanks BetteNoire,
That was useful information.

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I wondered the same thing myself a while back.

Apparently the same thing can happen with other stronger citrus fruits as well.

Citrus fruits are clearly evil lol