[dangerousanimals]

I used to take SeroquelXR 300mg, and I had to stop because of night sweats, dry mouth, muscle twitches, clenching my jaw and a skin crawling feeling.

I discovered that I could tolerate other meds of this type even less than Seroquel, so my new doctors let me try it again at a lower dose with the intent to increase as needed. I was at regular release seroquel 100mg in the morning and 200mg at night. Side effects at previous amounts were skin crawling sensation, night sweats, nightmares, dry mouth. My meds doubled yesterday because I'm hypomanic, and I expected to experience the worst skin crawling, drowning in sweat and nightmares. The skin crawling sensation never happened. I didn't wake up soaked in sweat either...nightmares were still weird, but they didn't wake me up repeatedly. I'm a little tired today, but where did the other side effects go?

Anyone else have less side effects as their dosage increased?

My research indicates that the most likely reason for the decrease in side effects was changing from extended release to non-extended release.

I take 400mgs of Seroquel (non-extended release) about two hours before bedtime with no known side effects. I have found that if I eat anything within four hours of bedtime I have weird dreams and wake up too early, so now I just drink Gatorade during those four hours before bedtime.

I hope this helps.

[dangerousanimals]

I was still having some of the side effects on the lower dose of the non-extended release (less severe, though).
I will try not eating anything in the few hours before taking it. It would be nice to have fewer nightmares.

[dangerousanimals]

Talked to a meds doctor. She said that this decrease in skin crawling sensation and other side effects would likely be due to the higher doses affecting different things in the brain. (Lower doses are more sedating, as the dose increases the medication impacts mood)

Up to Seroquel 200mg AM, 400mg PM. Taking 200mg all at once made me too sleepy today, so I'll probably have to take 100mg at 9am, and the other 100mg at 11am.
I get to check in again on Thursday.

[BlessedRhiannon]

I've talked with my pdoc about this too and he's told me that Seroquel is one of those weird drugs that acts differently at higher doses. So, side effects present at a low dose will go away at a higher dose.