[detour1]

Hi
i been on seroquel for a while now i used to take it at 5 and i need to take it at 5;30 to get to sleep ,i need to take it a few hours before i go to bed ,do you think an increase dose will help ? i am on 100mmg right now

[Travelinglady]

I don't know. I seem to remember it knocked me out quickly, but I don't remember what dosage I took. Have you told your doctor about it?

[detour1]

Originally Posted by Travelinglady

I don't know. I seem to remember it knocked me out quickly, but I don't remember what dosage I took. Have you told your doctor about it?

I go back next week for a follow up

[sonjaward809]

From what I've heard the lower the dosage the more sedating Seroquel is .. I'm on 50 mg PRN for insomnia and it doesn't do much. I used to be on a higher dosage a few years ago (can't remember the dosage but it knocked me DOWN) but I was pulled off due to weight gain. So now that I'm back on it I'm wary of how often I take it. I don't want an increased dosage but I might need to bump up to 100mg to get to sleep properly.

[TicTacGo]

Yes, lower does usually mean more sedating. My doctor explained that it has a paradoxical effect. The lower dosage binds more to histamine (H1) receptors. Thus causing sedation.

I have found that higher dosages make me sedated as well, though this seems to be classified as more of a side effect than the lower dosage and it's sedative effect.

[detour1]

Originally Posted by TicTacGo

Yes, lower does usually mean more sedating. My doctor explained that it has a paradoxical effect. The lower dosage binds more to histamine (H1) receptors. Thus causing sedation.

I have found that higher dosages make me sedated as well, though this seems to be classified as more of a side effect than the lower dosage and it's sedative effect.

Okay what is the best way to mention this my doctor ? how do i asked him if we can up it