Desipramine and heart issues

New member here, I've got questions about two of my medicines, so splitting my questions into two posts.

I was on desipramine several years ago and I remember that it caused prolonged QT interval. I no longer have any means of getting that EKG, but it had other things on it too, but they all referred to different parts of the electrical rhythm (QRS, T waves, stuff like that).

I lost insurance two years ago, goodbye meds and then goodbye stability. Got a new doctor, got back on medication, started to regain stability. I was so desperate for stability that I "conveniently forgot" that desipramine had caused prolonged QT interval before. This place is crap for mental health care and it took me a bit to find a good provider. Good provider meant a routine EKG to check my QT interval, surprisingly because I'm on Seroquel, not the desipramine.

Long story short, I've had 3 EKGs in the last year, plus a nuclear stress test and a heart ultrasound that were done after EKG #1. EKGs #1 and #3 say there's something wrong with the physical structure of the heart. The stress test says there's a problem but the reading cardiologist thinks it's a false positive. EKG #2 and the ultrasound showed a happy healthy heart.

So here's the question. Can desipramine be the cause of the oddities on both the EKGs and the stress test?

I'm already in the process of stopping the desipramine because my QTc is in scary territory (465) and we've pretty much determined it's not the Seroquel, as it didn't budge despite drastically lowering the Seroquel. I'm also waiting for an appointment to get a second opinion from a different cardiologist. I just need to hear if someone else had desipramine, or any tricyclic, cause wacky electrical and nuclear isotope conduction when everything was actually fine.

Hi tabitha120,

Welcome to PC.

I am not qualified to answer your question. I hope you do find answers with your qualified physicians. I hope your heart is healthy!

I want to welcome you. I hope you find the information and the support you may be seeking.
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Wild Coyote

Saw the cardiologist today, he says everything is great and chipper and to want to see me back would actually be unethical as there's zip to treat.

However it's not the desipramine causing the funny readings. It's not any of my psych meds. So if someone else is seeing this and has symptoms or a scary EKG, it's not the psych meds at all, see your doctor.