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Grand Magnate
Member Since Sep 2022
Location: na
Posts: 3,113
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#1
Antidep I've been taking for years [tried both generic & namebrand] don't seem to be doing much anymore. Wellbutrin is the name. Bupropion. Extended release. 300mg once a day.
Would like to hear from any long-term users of this med who switched to something they found to work better. |
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Poohbah
Member Since Aug 2022
Location: The House
Posts: 1,200
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#2
I take Wellbutrin 300 mg once a day, but I also take Prozac 40mg in the morning and in the evening: mirtazepine (Remeron) 30 mg. Mirtazepine has really been good for me as it's fast acting, takes away SI and helps me sleep.
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Crazy Hitch, mar dhea
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Crazy Hitch, mar dhea
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Grand Magnate
Member Since Sep 2022
Location: na
Posts: 3,113
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#3
Hi. May I ask how long you've been taking Wellbutrin? I've been taking it at 300mg daily for over 20 yrs now. I've also switched back and forth from name brand to generic several times. Wondering if I've worn it out. A significant uptick in bad days [versus decent days] is beginning to worry me. Has been for about a year now. Could be other factors involved in that but maybe making a med change/s is the best first step? Thank you for answering TG.
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Poohbah
Member Since Aug 2022
Location: The House
Posts: 1,200
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#4
Yeah, I can see why you're thinking of changing meds.
I've been taking Wellbutrin for 9 years now. But, for me, it's the mirtazepine that seems to work best for me in terms of rapid symptom relief. I think I'd be less stable, if I didn't have the others, though, including the antipsychotic Abilify, also PRN Ativan. I'd like to look into gabapentin for anxiety... Let us know if you change meds and how you do... |
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mar dhea
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Grand Magnate
Member Since Sep 2022
Location: na
Posts: 3,113
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#5
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TheGal
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Poohbah
Member Since Aug 2022
Location: The House
Posts: 1,200
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#6
I know it's so hard getting treatment and not knowing what we don't know. And let's face it, it is difficult to advocate for ourselves, espeically when we're not feeling well. Then it happens that feeling poorly (or less than optimal) becomes normal.
But let's not blame ourselves. Let's practice self-compassion... we deserve it!! It's good you'll have the conversation about your meds with your psychiatrist. An antipsychotic may or may not be what you need, but it's worth having the conversation. My Dx is severe major depression with psychotic features. I hope you feel better soon... Take good care... Hugs, if wanted. |
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Tart Cherry Jam
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Magnate
Member Since Mar 2021
Location: California
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#7
I have an acquaintance with MDD w/o psychotic features for whom several ADs have lost their effectiveness, including Wellbutrin and Prozac. It is a difficult situation to handle.
__________________ Bipolar I w/psychotic features Last inpatient stay in 2018 Geodon 40 mg Seroquel 75 mg Gabapentin 1200 mg+Vitamin B-complex (against extrapyramidal side effects) Long term side effects from medications, some of them discontinued: - hypothyroidism - obesity BMI ~ 38 |
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Grand Magnate
Member Since Sep 2022
Location: na
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#8
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I'll soon see how it all goes. Or starts anyway. Appointment on 20th. Hugs ok! ((hugs back)) |
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TheGal
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TheGal
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Grand Magnate
Member Since Sep 2022
Location: na
Posts: 3,113
(SuperPoster!)
2 1,113 hugs
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#9
Quote:
Hi. Thankfully the list of meds that operate with differing recipes is long and has been growing. I hope everything works out. Beginning everything all over can be tough but can also be the best thing one can do. |
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Tart Cherry Jam
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Member
Member Since Mar 2024
Location: In the southern United States
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#10
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mar dhea, TinyDancer123
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Member Since Jan 2013
Location: Madison, Alabama, USA
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#11
Quote:
Also, you could ask your pdoc about adding sertraline (Zoloft). It's a great adjunct to bupropion because it's a CYP2B6 inhibitor, which inhibits bupropion's metabolism to hydroxybupropion, which is primarily a norepinephrine reuptake inhibitor. Adding sertraline balances out the dopamine reuptake inhibition relevant to its norepinephrine reuptake inhibition, plus adding serotonin reuptake inhibition to the mix. Also, sertraline is a mild dopamine reuptake inhibitor to boot. __________________ Diagnoses: Tourette's Disorder, OCD, ADHD-PI, Bipolar I Disorder, Borderline Personality Disorder, Anxiety Disorder Unspecified Medications: Dyanavel XR 15 mg 30 mg/day Lamictal 300 mg/day Cymbalta 90 mg/day Lunesta 3 mg/night Dayvigo 10 mg/night |
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mar dhea
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