[Sherryanne]

I have recently been diagnosed with polycyctic ovary syndrome and endometrial hyperplasia both due to hormonal imbalances.

Due to what I have read I suspect that both my conditions were caused by my risperidone which I have been taking for 11 months. I also have elevated prolactin levels.

They put me on birth control to try to restore my hormone's natural levels. My fear is that if I continue to take the risperidone, will it counter act the birth control and prevent my hormone levels from stabilizing.

Has anyone ever had any of these conditions?

Would really appreciate anyone's help

[Larry_Hoover]

Risperidone is notorious for raising prolaction levels, and it could conceivably lead to the development of PCOS and endometrial hyperplasia, but I would be really surprised that this could happen in eleven months. I suspect that you already had a tendency towards these disorders, and the risperidone magnified the trend.....

I think the best thing for you is to discontinue the risperidone, and have your doctors closely monitor your hormone levels. PCOS and endometrial hyperplasia tend to occur together, and risk factors are high insulin levels (pre-diabetes or insulin resistance) and excess body weight and/or high blood lipids. The characteristic hormone imbalance of PCOS is very high androgen levels, with low progesterone, so if these persist after you're off risperidone, then it's pretty unlikely that risperidone was the sole cause. You could have a pituitary tumour, for example, or an adrenal disorder, or a steroid hormone enzyme deficiency. The risperidone would make it much harder to determine what's happening. If the birth control pills have significant amounts of progesterone, that might take care of the endometrial hyperplasia, but it wouldn't change the hyperprolactinemia, which could come from the drug, or from something else going on in your body.

If you're not being seen by an endocrinologist, or gynecologist specializing in reproductive hormone disturbances, I'd strongly suggest being assessed by one, if going off risperidone doesn't resolve your symptoms.

Lar