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justanotherone97
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Unhappy Sep 16, 2016 at 12:30 AM
  #1
i am currently taking 3 but nothing works:

- citalopram (60mg) works
- brintellix (10mg) stopped working after 5mg
- anafranil (150mg) doesn't work
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Logan200000
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Default Sep 18, 2016 at 01:06 AM
  #2
Quote:
Originally Posted by justanotherone97 View Post
i am currently taking 3 but nothing works:

- citalopram (60mg) works
- brintellix (10mg) stopped working after 5mg
- anafranil (150mg) doesn't work
Yes, I take three. It took a long time to find the right combination, and it's still not perfect by any means. But I think it makes sense to work with a doctor to figure out the right combo, even if it takes a while. Many people (like you and me) will need to explore combinations and use more than one. At least, that's what I've read and that's what my doctor believes as well.
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Default Sep 19, 2016 at 03:32 PM
  #3
I used to take 2 and a mood stabiliser it helped for quite a while but the mood stabiliser no longer helps so I'm now on one with a small dose of quetiapine at night to reduce agitation and anxiety. The quetiapine makes the most difference to my quality of life.

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Deejay14
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Default Sep 30, 2016 at 10:28 AM
  #4
Two anti depressants and ability.
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Default Sep 30, 2016 at 10:34 AM
  #5
I take 2, Effexor & Prozac, with Latuda.
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Default Sep 30, 2016 at 05:26 PM
  #6
Yes...I take Zoloft, Latuda, Trileptal, Klonopin, and Seroquel.
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katonalim
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Default Oct 02, 2016 at 01:00 AM
  #7
Yes, my current "cocktail" is Lamotrigine, Mirtazapine, Trintellix, Zopiclone (for sleep - ha ha), and to kick start my mornings, Dexedrine Spansule. It has taken a little over 2 years this time to come up with something that has any effect - I am by no means better, but I know I am better than I was.
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eyesclosed
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Default Oct 06, 2016 at 09:14 PM
  #8
yeah20mg flouxetine 40 mg paroxetine 60mg adderall 2mg alprazolam can sit in the dark all day with my eyes closed eyesclosed
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kecanoe
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Default Oct 09, 2016 at 08:55 PM
  #9
Wlebutrin, Buspar, nortryptylene. For a while with Abilify. And I have tried a whole bunch of others. Like 15 or more. Ridiculous.

The good news is that after 6 years of crushing depression despite all the drugs and lots of therapy, I am now feels no better and titration off my meds.
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unhappydaze
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Default Oct 10, 2016 at 03:50 AM
  #10
Yes, there has not been a time within the last four-plus years that I haven't been taking more than one. For the last 9 months it's been

Lamotrigine (Lamictal) 200mg /day
Nefazodone (Serzone) 600mg /day
Buproprion (Wellbutrin) 450mg /day

Two weeks ago pdoc prescribed a new one called Vraylar (caraprazine) .75mg /day. Technically it is off label - it is nominally for bipolar and schizophrenia - but so far it seems to be having a positive effect for me beyond placebo. (I'm your basic treatment-resistant depression and/or dysthymia, depending who's doing the diagnosis, so we'll see how it holds up.)

Other than that, the Wellbutrin (buproprion) has some beneficial effect, though it waxes and wanes. The other meds, no effect I can tell, but for now I have no reason to reject them, as they have very little side effects, so for the moment I defer to pdoc's judgment as to efficacy.
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Default Oct 10, 2016 at 08:53 AM
  #11
No I wish I could tolerate even one antidepressant

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daisytrain
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Default Oct 10, 2016 at 03:09 PM
  #12
I am on three at the moment. Have tried so many combinations and nothing really works. Right now I'm taking Wellbutrin, Ritalin, and one that I can't recall at the moment but starts with a L.
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BAR459
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Default Dec 11, 2016 at 11:11 PM
  #13
I take Cymbalta for fibromyalgia/depression, Ambien for sleep. Believe me, I've taken everything out there to conquer this awful depression and I have gained weight and had so many side effects, such as no sleep. I have tried anything out there since 3 years ago. Any thing working for you? Did you have problems with lack of sleep, weight gain and hard to get up the next morning from Ambien. I've gone 5 or more days without and no sleep. So frustrating.
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Default Dec 13, 2016 at 03:18 PM
  #14
oh my yes...... effexor xr 600 mg.
wellbutrin xl 450 mg.
abilify 15 mg.
klonopine .5 mg
seroquel for sleep 100mg.
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Butterfly31
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Default Dec 15, 2016 at 01:07 AM
  #15
I'm taking Latuda, cymbalta, diazepam, vistaril, prazosin(off-label), gabapentin
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Bluesday
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Default Dec 15, 2016 at 02:55 AM
  #16
Wellbutrin, Lexapro, and Abilify.
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steelcurtain27
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Default Dec 19, 2016 at 03:34 PM
  #17
Over the course of 9 years I've been on 29 different meds and combinations of meds. Currently, I'm taking .625 mg of Rexulti (if I take less it seems less effective than it already does and if I take more it seems to make me hypomanic), 350 mg Topamax (for mood and migraines), .5 mg Klonopin twice a day, and 10 mg melatonin. Nothing seems all that effective, I don't really want to add anything since I take a lot of other meds for other health issues.
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Lamb1219
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Default Dec 28, 2016 at 02:11 PM
  #18
Yes, I am on Prozac and Wellbutrin. I too suffered with medication resistant depression and the one thing that helped was I had ECT treatments and then the antidepressants helped.
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nicoleb2
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Default Dec 28, 2016 at 09:51 PM
  #19
I've been on probably 40 meds/med combos in the last 10 years.
Currently, I take:
Wellbutrin 300mg
Effexor 300mg
Buspar 7.5 twice a day
And, for sleep:
Ambien 10mg
Trazodone 200mg
Seroquel 200mg
Neurontin 300mg

Plus vitamin d and also verapamil for migraine prevention.
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samj40
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Default Dec 30, 2016 at 05:41 AM
  #20
I'm on Effexor XR 150mg and mirtazapine 30mg.

The Effexor is the only medication that's ever helped but it only helps for maybe 6 months and it stops having an effect whatsoever. No other SSRIs or SNRIs help at all.

The mirtazapine does essentially nothing, but it at least limits my insomnia to two-three nights a week instead of all week.

I'm also on some anxiety meds for when things get too bad, but they don't even make me groggy or limit my depression induced anxiety, so welp to those.
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