it is the second day of a new combination therapy. duloxetine and bupropion XL. Because of interaction, the duloxetine dose is cut in half, and I think I am feeling that. I don't feel better. I don't have more energy. yet. I know I need to be patient about this. I have just been on the edge of surviving for so long. bobbing up and down in the black hole. Always exhausted. I have to try this. My life is living without me.