But if it is a "thing" and you find nothing works in 2 med combinations would you move on? I'm also curious about this because I never really had the chance to have ground rules about "I won't gain more than _" "won't take more than _" "won't take meds from ____ class" etc. The best I had was that I was afraid of Seroquel b/c the psychiatrist where I used to work used it to snow people and I was terrified that it was what the drug did so we didn't use it until a last resort and I didn't want Zyprexa b/c my family history with diabetes is pretty scary. But then I took Seroquel and it was fine and still is (although I gained weight and have side effects but I'm also on a lot of it) and I tried Zyprexa and it did nothing for me so the diabetes wasn't an issue although it remains something we're cautious about with Seroquel. So far my blood sugars remain great and I've been on Seroquel 8 years so hopefully my genetics don't kick in and I stay free of diabetes since I don't need anything else to deal with.