I've never been in that situation, so it's hard for me to say with conviction. I'm fairly new to trying meds after years going unmedicated (aside from a few shots at SSRIs which went horrendously). I feel like it's a "thing" for me, because I don't like the idea of not being able to tell what is coming from which med(s), be it good things or bad. On many meds I would feel like I was just being hammered in a suppression sort of way, at which point I'd feel like just give me some damned valium already and call it a day.