I have restless leg syndrome, but I don't think it's caused by meds. It hardly bothers me if I take a calcium supplement along with a magnesium supplement before bed. If you try this, go easy on the magnesium, especially at first, it can cause diarrhea. I was on a medication once it treat it, and it didn't seem to help. If I don't take the supplements, after a few days, it gets bad though drinking milk & eating a banana can help it enough to fall asleep. Acupuncture helped with it though.

Another possibility is you can also get vitamin toxicity, in which case you might have to see a neurologist. I had a lot of that tingling sensation, numbness, swelling, and it turned out I had too much vitamin B6 in my system, like by a thousand times or more. I was taking a women's multivitamin from a health store that had high B6 levels (high levels of most of the vitamins & minerals, I think), drinking a before or after workout shake with more B6, and then of course, things like cereal are fortified with vitamins, including B6. The kicker about B6 toxicity, is no one knows how long it can last. It can go away a few weeks after stopping the B6, it can go on months or years or even for life. I have finally gotten to the point where I can take a normal women's vitamin (not something all fortified with high levels of vitamins) and eat cereal again, but it took my over a year before all the symptoms went away and I could do this. I saw a neurologist who diagnosed it.

Hubby had numbness & tingling and his turned out to be low B12. He had to have a series of 4 B12 injections in a month, and now one injection once a month for 3 months, and then they are going to check again. One of my sisters, though, has something like pernicious anemia caused by low B12 (somehow not caught by a normal CBC) and has to get B12 injections either once a week or every two weeks basically for life. They don't know what causes it.