Not all guilt is rational. Following a series of epileptic discharges as a teen (not sure if it qualified as status epilepticus), I lost all my positive emotions as well as my libido. All I had to work with was a sensation of profound hopelessness, and irrational guilt. I wasn't aware of having done anything to make me feel guilty, but I would have confessed to anything if it promised to relieve me of that guilt sensation. It took some time, but I regained most of my emotions and libido, and the guilt subsided. I came across a book "The Broken Brain" by psychiatrist Nancy Andreason. In it she told the story of a lady with a depressive disorder who experienced irrational guilt. I recognized it as what I had experienced. It seemed real at the time. So did the hopelessness. That was difficult to overcome. It was all pathological.
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