[Marshellette]

The "haze" of mania produced by excess PKC may be somewhat familiar to anybody who's ever been foggy after a really huge meal. The major difference between bipolar patients and people without bipolar disorder is that most people who have post-prandial high blood sugar tend to feel sleepy or otherwise relax. In contrast, those about to go into a manic episode will experience a burst of unlimited energy along with rapid and pressured action and speech, an overwhelming feeling of seeing it all, and a need to act NOW. Interestingly, both Wolfram syndrome and a rare form of bipolar disorder identified by Japanese scientists have been traced to defects in the endoplasmic reticulum, a cell structure with many jobs, including that of taking up glucose into the cell. This suggests that sugar metabolism may play a role in other types of bipolar disorder.

[bluekoi]

Marshellette, Thanks for sharing this. Sounds plausible.

[moremi]

Thanks! That very interesting

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[spydermonkey]

this is really interesting to me. do you have some sources where i could read more about this? and what is pkc?

Originally Posted by spydermonkey

this is really interesting to me. do you have some sources where i could read more about this? and what is pkc?

PKC = protein kinase C, an enzyme.

The original post is an excerpt from this article: Tracking down the Footprints of Bipolar Disorder

[Dix888]

Fascinating! Will read the article. Thanks!