I've been on 50 mg of Zoloft for almost a month now (monotherapy). When I first started at 12.5 then 25 I felt great...almost too great (I described it as waves of feeling like I was on crack or something). Then everything seemed to level out, but now for the past 10 days or so I feel both depressed and energized at the same time. I am filled with sadness, hopelessness, confusion, and self-loathing on the one hand, and then on the other I feel a need to do things and be productive...but I have no motivation or direction at all. it's horrible because I can't just sleep or lay around even...thoughts are racing and I basically just end up staring at the computer or tv because I can't decide what to do, as everything seems too hard or meaningless. I also thought my anxiety was getting better, but now it's just as bad as before. I don't know what to do or why this is happening...

[gayleggg]

Zoloft may not be the med for you. I suggest you talk to your doctor and see what he suggests.

[wildflowerchild25]

It could be a mixed episode. Have you been formally diagnosed with bipolar disorder yet? I ask because it's generally not a good idea to treat bipolar with an antidepressant alone, as it can lead to mania or mixed episodes. I try to stay away from antidepressants altogether but a lot of people can be on them with the help of a mood stabilizer. Having all the energy of a hypo/manic episode but the thoughts/feelings of depression usually constitutes mixed for me. That's the worst place for me to be. It's the most uncomfortable.

[BlackSheep79]

I agree with wildflowerchild that this sounds like a mixed episode. I'm no doctor but I was diagnosed with mixed episodes and I dealt with mixed episodes, it's the worst for me. Like stated anti-depressants can put you in a manic state which happens to me. I would suggest talking to your pdoc.

BP 1- mixed episodes/OCD

Lamictal 400 mg
Latuda 80 mg
Ativan 1.5 mg

50mg is a small dose, are you sure there is not anything else in your life affecting you?

[optimistic_dolphin]

yup, it sounds like mixed episode. I felt the same way before
antidepressant makes me high, so my dr doesn't prescribe them to me
does your doc knows your bipolar? or only depressed?

[Curiosity77]

Sounds mixed to me too.

[~Christina]

I agree with everyone else .. Sounds mixed to me .. They are horrible .

Stay safe

Okay, I can only share my own experience. I am bipolar. I started taking Zoloft some months ago (200mg). I was slammed with the most worst angst/agitation/mixed state AWFUL mood issues imaginable. My p-doc said he believed the Zoloft was causing me to have "negative mixed-state hypomania". I dropped the dosage and immediately felt better. I'm now down to 25mg Zoloft and the positive change in my moods is remarkable. I plan on going off Zoloft altogether. Oh - also, I have seen a number of threads on PC about Zoloft setting off negative manias for people who are bipolar.

Thanks everyone for your input. I ended up getting into a fight with my father last night (whom I'm staying with for the summer) and packed up all my things and started driving to NY without telling anyone...woke up in a hotel really depressed and decided to turn around. It's so hard to tell where this is all coming from and whether I need to increase Zoloft or get off it ASAP! Unfortunately since I recently moved I can't see me psychiatrist, have an app with a new one on the 12th but really wish I could see my old one...
One of the reasons I decided to take the Zoloft was for diagnostic purposes - to see if I really am bipolar or just very anxious, but now I'm just more confused