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#1
Jan 07, 2016, 07:10 AM
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So alcohol & any kind of benzodiazepine usually improves my dysphoric feelings. So I figure anything that affects GABA? I do have a GAD dx but the dysphoric feeling is different from anxiety I've experienced in the past including during panic attacks. My original pdoc thought it was a bipolar symptom as it got significantly worse on AD mono therapy. Has anyone got any experience with the mood stabilisers that affect the GABAergic system?
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Dx: Bipolar II, GAD, past substance abuse, temporal lobe epilepsy. Rx: Lamotrigine 125mg, Sertraline 50mg, Clonazepam 0.5mg prn. |
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#2
Jan 07, 2016, 08:58 AM
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Hello wonderlust.
I think all mood stabilizers affect the GABA neurotransmitters. Usually when the brain suffers chemical imbalances affecting mood, GABA malfunction is to blame since it is an inhibitory neurotransmitter and its job is to reduce neuronal excitability which seems to be the case in GAD and other, mood disorders. Alcohol and benzos usually act as inhibitory agents so I'm thinking that's why they seem to help. I really couldn't tell you what may be causing the dysphoria. Still hope this helped a bit. Be well.
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Bipolar I with psychosis “If I am mad, it is mercy! May the gods pity the man who in his callousness can remain sane to the hideous end!” |
 Wanderlust90
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