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Grand Magnate
Member Since Sep 2015
Location: Michigan
Posts: 3,504
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#1
I'm frustrated! Years ago I could fall asleep on 100mg. Then that had to be increased over and over and I'm now up to 450-600mg for sleep. Is that a high dose? I don't want to go up anymore because I feel like crap the next day. So what's everyone else's dose??
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Sunflower123, xRavenx
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Elder
Member Since Mar 2017
Location: Florida
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#2
When I was on Seroquel 50mg what knock me out 600 not even the least bit tired. Now I am on Zyprexa 5mg and I want to sleep 20mg and I am wide awake. These meds tend to be sedating at low dosages for me. They are activating on high dosages.
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Magnate
Member Since Aug 2016
Location: New York
Posts: 2,075
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#3
Seroquel is commonly dosed up to 900mg. I've heard of 1200 and 1500, but I don't think that's very common.
__________________ Meds: Latuda, Lamictal XR, Vyvanse, Seroquel, Klonopin Supplements: Monster Energy replacement. Also DLPA, tyrosine, glutamine, and tryptophan |
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Poohbah
Member Since Apr 2016
Location: NY
Posts: 1,168
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#4
I've been on all sorts of dosages, and they all cause me to oversleep. Currently at 300mg, down from 900mg a few months ago.
__________________ dx: schizoaffective bipolar type; OCD; GAD rx: clozapine, clonazepam PRN |
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Veteran Member
Member Since Jul 2016
Location: Midwest
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#5
That's a very high dosage if you're using the Seroquel just for sleep. Seroquel works only as a (sleep-inducing) antihistamine at doses up to around 150mg. After that its use as an antipsychotic kicks in. The antipsychotic effects may in fact negate the sleep-inducing antihistamine effects. Doses of 450mg or even more are used to prevent manic and depressive symptoms.
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*Laurie*
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Magnate
Member Since Jun 2016
Location: U.S.
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#6
For mood stabilization for acute Bipolar Type 1 episodes 400 up to 800 is the range, according to my psychiatrist....occasionally 300 mg for some, but more for BP2 hypomania/depressive prevention. AP effects start to take place at 600 mg, but sometimes less, depending on the person. Anything lower than 200 mg is typically for sleep. 450 is a moderate dose in general, but some would say it is actually less sedating than lower doses (Seroquel is weird like that). I still find it sedating though...just takes longer to get to bed.
I was on 600 mg for a while and recently lowered to 400 mg, because I was sick of feeling even more irritable and had some scary side effects, such as occasionally having problems breathing at night. 400 mg is working out better, now that the higher dose wiped out my state of "acute mania". It's a good mainenance dose. I might need to go taper up again at times, when there's signs of flare ups/onset of episodes. I developed somewhat of a tolerance getting to sleep with Seroquel, but only in the sense that it takes longer to kick in. Once it does though, it still knocks me out. That effect will usually happen a few hours after taking it, where it used to be in a shorter time frame. I have to take it much earlier than I used to, so that I don't feel like crap and dizzy before work. I'm not feeling as much of a hangover on 400 though. 600 mg sometimes would make my blood pressure drop and difficulties driving. |
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Grand Poohbah
Member Since May 2016
Location: Chicago
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#7
My pdoc says that anything over 800mg tends to be too much, but that there are some people who need it. I started at 100mg in March then went to 300mg last month and now I'm at 400mg. I'm hoping that I won't have to go any higher than this and that he doesn't have to add anymore meds to my cocktail. So far he's been very good about keeping the amount of meds I'm on low. The fewer the better I say.
__________________ Dx: BP2 and MDD Current meds: 100mg Wellbutrin; 200mg Lamictal; 400mg Seroquel at night; Xanax 1mg/PRN; 100mg/PRN Trazodone at night for insomnia Diagnosed in May 2016 |
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Magnate
Member Since Oct 2014
Location: jakevill
Posts: 2,622
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#8
seroquel works different for everybody. it is approved at 150mg for depression and that works for me. when I was manic of course it was much more. when I used it as maintenance I wouldn't go past 400mg because it felt like my soul was murdered. no thanks to zombieland
__________________ I used to rule the world Seas would rise when I gave the word Now in the morning, I sleep alone Sweep the streets I used to own I used to roll the dice Feel the fear in my enemy's eyes Listen as the crowd would sing Now the old king is dead! Long live the king! One minute I held the key Next the walls were closed on me And I discovered that my castles stand Upon pillars of salt and pillars of sand |
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JustJace2u
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#9
I've been on higher doses of Seroquel, but right now I'm on 25mg. specifically to help my sleep. Every dose I've been on, however, helps with my sleep.
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bizi
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Silver Swan
Member Since Jan 2008
Location: USA
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#10
Quote:
__________________ Ingrezza 80 mg Propranolol 40 mg Benztropine 1 mg Vraylar 1.5 mg, Gabapentin 300 Mania Sept/Oct 2024 Mania (July/August 2024) Mania (December 2023) Mixed episode/Hypomania (September 2023) Depression, Anxiety and Intrusive thoughts (September 2021) Depression & Psychosis (July/August 2021) Mania (April/May 2019) |
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jacky8807
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Magnate
Member Since Oct 2014
Location: jakevill
Posts: 2,622
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#11
__________________ I used to rule the world Seas would rise when I gave the word Now in the morning, I sleep alone Sweep the streets I used to own I used to roll the dice Feel the fear in my enemy's eyes Listen as the crowd would sing Now the old king is dead! Long live the king! One minute I held the key Next the walls were closed on me And I discovered that my castles stand Upon pillars of salt and pillars of sand |
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Magnate
Member Since Aug 2016
Location: New York
Posts: 2,075
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#12
__________________ Meds: Latuda, Lamictal XR, Vyvanse, Seroquel, Klonopin Supplements: Monster Energy replacement. Also DLPA, tyrosine, glutamine, and tryptophan |
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jacky8807
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#13
Seroquel gives me bad dreams every. single. night. I've secretly switched to diphenhydramine and will confess this unauthorized change to my pdoc at my next appointment. My pdoc has a different personality every time I see him, so I can't predict how he'll react.
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bizi
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Grand Poohbah
Member Since Sep 2015
Location: Alberta canada
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#14
When I was in hospital I was put on 800mg of seroquel and I felt like a zombie but it pulled me out of a psychotic episode.
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Member
Member Since Mar 2017
Location: East Coast, US
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#15
I take 800mg of Seroquel XR and I'm not zombified and I don't feel flat or over medicated. It worked to take me out of a mixed episode last month and the only complaint I have is that it makes me oversleep in the morning. Otherwise, it works for me. I started on 600mg and had to go up as 600mg was not controlling the agitation I had with the mixed mania. I've had good results but I understand everyone is different when it comes to medication.
__________________ Bipolar 1 ADHD Carbamazepine (Tegretol) Vraylar Desvenlafaxine (Pristiq) Mirtazapine Adderall XR My Journal https://jenniferforreal.wordpress.com/ “Those who love you are not fooled by mistakes you have made or dark images you hold about yourself. They remember your beauty when you feel ugly; your wholeness when you are broken; your innocence when you feel guilty; and your purpose when you are confused.” ~ Alan Cohen |
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New Member
Member Since Aug 2017
Posts: 9
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#16
I take 100mg of Seroquel every night . Comming down from 200ir and 300 xr, while I wasn't so stable. I find it good and bad hating the weight gain from it but it seems to keep me level
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Wise Elder
Member Since Apr 2015
Location: US
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#17
I was on 1200 of XR for years and up to 1500 mg in the final months while we tried to get it to work just a little longer.
One trick that worked for me for years with the XR was that I took nearly all of my dose as XR and broke one tablet which made it instant release. That helped me fall asleep but then I was so knocked out in the morning compared to taking 800 mg of IR at once (I couldn't have done this; 600 was the max I could take of IR and work. I begged to go on ER as soon as it was released). It made a difference for sure; a couple times when I was IP they didn't have XR and I was given IR. I'd go in complaining of not being able to sleep for weeks or months and then they'd give me 800-1200 IR and I was out like a light for a few nights until my body adjusted again. __________________ Bipolar 1, PTSD, GAD, OCD. Clozapine 250 mg, Emsam 12 mg/day patch, topamax 25 mg, ,Gabapentin 1600 mg & 100-2 PRN,. 2 mg clonazepam., 75 mg Seroquel and 12.5 mg PRNx2 daily |
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Crone
Member Since May 2010
Location: Some where between my inner mind and the solar system.
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#18
I was on seroquel for years but I can't say much about it cause I had a low soul sucking threshold and my memory of those years is fuzzy at best, completely blank at worse. Dose? Don't know, what I do remember is restless legs , oh painful.
__________________ Nammu …Beyond a wholesome discipline, be gentle with yourself. You are a child of the universe no less than the trees and the stars; you have a right to be here. …... Desiderata Max Ehrmann |
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Insert Smiley Face
Member Since Mar 2015
Location: USA
Posts: 6,233
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#19
I was on 300mg for awhile. It totally washed me out. I was tired and grumpy all of the time. I didn't laugh for months. It changed my personality. It made me gain weight, get bloated, constipation. It knocked me out at night though. No more seroquel for me!
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Magnate
Member Since Jun 2016
Location: U.S.
Posts: 2,585
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#20
The 400 range never gave me significant side effects. Once I hit 600 mg though, I started experiencing low blood pressure( only if I were to get out of bed too fast), and sometimes a hard time driving in the morning from the fatigue and dizziness, unless I slept at least 10 hours, increased appetite, and I would get twitchy, especially in my wrists. Some of the stronger side effects would go away after the morning time, such as the fatigue. I needed lots of coffee. It did help with racing thoughts to a degree.
Anything below 600 wasn't bad though. Now, I keep myself at 400 or during times I am not actively in a severe mixed or manic episode, I'll go down to 300 mg for as long as I can. We're always tweaking my Seroquel dose to keep up with my moods, but it's a good medication for me overall since I suffer from bad insomnia, and that almost always leads to a form of mania in me. I really don't like higher doses unless I'm in crisis and no other interventions are helping. |
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