I was diagonised with Bipolar last Sept. and was hospitalized then for about a week or so. Then in Jan. 2010 sunk into a deep depression and was hopitalized in Feb. for about 2 weeks. I have been on countless medicines, all to no avail. My PDr suggested I try TMS which I just finished last week. It was 6 weeks of long driving and a ton of money, but I still feel depressed- anhedonia seems to have taken over my life! I've found no joy in anything or anyone for almost 11 months. I go to a counselor every two weeks, and she said that I seem to appear a bit better, and then that session, I was able to cry, which I hadn't done in 10 months. I've cried a few more times in the last 2 weeks, but there is no joy in anything. I am switching my PDr. in Jan. and going to the Dr. who did my TMS, since he switched my meds, and the other PDr. said that he didn't know what to do for me, and that I was treatment resistant to meds. During my last 2 weeks of TMS, that Dr. put me on Symbyax 12/25 which I take at night, Nuvigil 150 mg., Wellbutrin Cr 150, Levothyroxide for low thyroid, which the TMS Dr. found out through getting blood work done, Clonapin 1mg and Dioxipin 150 to help me sleep. ( these 2 I have been on since Jan 2010) I feel that I'm at the end of my rope and still have a constant whole in my heart and soul. The TMS PDr. said to give these new meds some time to get in my system and work. I do have more energy since TMS and med changes, but I find no joy in life. I just moved back into my husband's bed after sleeping in another room since Jan. 2010. We have no sex life! I just want to be happy when I see my grandchildren or a beautiful day. My regular Pdr was not happy about the changes made in my meds by the TMS DR. I am going to one more appointment with my old PDr.in Dec. and then going to the other PDr in Jan since he seems willing to listen to me and try new meds, and he's the one who found that I have low thyroid levels. I'm looking for the right medicines to help me, and I'm looking for a way out of this continual depressive state. I don't want to do ECT at all! Any suggestions?