[MattMVS7]

My focus is on treatment and what I need that could help me and I am currently experiencing anhedonia that is there all the time everyday despite the fact that the depression itself is gone.

Now I realize that scientific theories regarding depression and anhedonia are just theories--they are not facts. But I am willing to try supplements and such according to scientific theories to see if they help or not.

One of these theories regarding anhedonia is right here:

Scientists identify potential target for treating anhedonia - major symptom of depression

Since melanocortins might be the problem here, could you give me the name of the supplements and such that I need to take that will address this issue with the melanocortins (like something that will block the MC4 receptor or anything else I need to take that will somehow address this issue with the melanocortins in a different way)?

[Altered Moment]

I am so glad to hear you are focused on treatment. I am not familiar with what you are talking about but supplements you may want to research and do have some studies and evidence behind them are....

SamE
5HTP
Vitamin D
L Tryptophan
L Methyfolate
Fish Oil
Melotonin

These have all been recommended to me by psychiatrists. I am not good about following up with consistently taking them.

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[Altered Moment]

I read the article and it is interesting. Stanford is on the cutting edge of these issues a long with John Hopkins and others. I would say it is too new to know which supplements or drugs may effect that circuit. It is another small piece of a very large puzzle. There have been studies on stress hormones contributing to depression. Cortisol and epinephrine.

I would strongly suggest meditation.
Exercise
Relaxation techniques
Anything to reduce stress and the high levels of those hormones.

It would not surprise me one bit if meditation has a large impact on the circuit in the study.

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