[FMLAMAN]

I posted this because I'm very sure most here, at one point or another have tried and failed at one or more non-prescription drug therapies for their chronic Depression. (In the past this had also failed for me so you're not alone.)

This was because in the past I had failed to gather the proper information to get results without medication. Before I post this info I would like to clearly state: DO NOT JUST GET OFF YOUR MEDS OR ATTEMPT THIS WITHOUT THE HELP OF A VERY GOOD HOLISTIC DOCTOR THAT IS ALSO HIGHLY TRAINED IN THE NATURAL TREATMENT OF SEVERE DEPRESSION.

I would also not advise this EVER, unless you have spent many weeks of your own study to fully understand the proper ways and fine understanding of how to use various supplements so that they are effective and safe. (I know... not easy to do when Depression has your focus level down to that of an 8 year old child with ADD.) That is why I posed this info. I like it because it's not overly complicated. As for bi-polar I cannot be sure on this data. I focused only on my 24 year condition which has never been diagnosed as any form of bi-polar. Although I'm very sure there is a holistic approach to bi-polar also, but PLEASE DO NOT CONSIDER THIS IF YOU ARE BI-POLAR BECAUSE HOLISTIC TREATMENT FOR THAT MAY BE VERY DIFFERENT FROM THIS.

I'm sure many might think, "that wouldn't work for me because obviously my Depressive condition is far worse than his." That would not be true at all. I'm 45 Years old and was hit hard with non-situational and VERY severe Depression and Anxiety at age 22. Since that time I have been on more medications of every class you could imagine and all at higher dosage and for plenty enough time for them to either work, not work, make me worse, and a select handful across time that worked great, but only to slowly fail in their AD benefit. Then me falling back down to a deep well while various Psychiatrist tried different meds to get me back to the living. On occasion we hit on one that worked, although over many years I came to know the length of time in which an effective medication would keep working was limited. Some working from 6 months to as long as 3 years, but all eventually failing. 4 years ago the MAOI-A Parnate was the only drug left that would work for me. Every other class of AD drugs that mostly effect Norephinepherine would no longer work. Even if I revisited an SNRI, or Tricyclic that years ago had been effective, the result was like taking a sugar pill if I tried them again. SSRI's were 100% Non-Effective.

I don't like to use the term "poop out" any longer. I do not believe this to be a building up any particular AD drug in terms of resistance. Any working drug I was taking was still working, but it had just tapped out all the very little naturally occurring neurotransmitters left in my brain. Can't get water from a dry sponge. Over time and through my own observation it became very clear that my deficiency was Norephenepherine and not so much Serotonin or Dopamine. Knowing this was critical for me to chart a natural supplemental course of treatment. Also gaining the understanding that most often there are other nutrients that must be in heavy play so that, "For example in my case L-Tyrosine could have any hope of breaking the blood brain barrier to be effective to highly boost levels of Norephinepherine in my brain for therapeutic result." Just taking L-Tyrosine will never work unless your including other things it needs to work.

My Psychiatrist was dead set against me getting off MAOI even though after 4 years it was working only to 30% effect and my physical side effects and health were in decline from Parnate. (Even with my perfect adherence to all food restrictions I started having frightening side effects with my heart beat.)
I decided then to suffer and go full steam ahead with a more sustainable approach using Amino and other key supplements. This was very difficult and during the crossover I could not even get out of bed to go pee. In 25 plus years I had NEVER been off of some kind of AD medication and often times with augmentation. I'm sure you can imagine how dreadful my symptoms of discontinuation were and for how long they lasted... In fact my discontinuation symptoms lasted so long I was actually worried that after so many years of AD and other meds that they had caused permanent Neurological damage. Not to mention that because I had been taking 50mgs a day of MAOI-A that I had to wait 4 long weeks before I could even start my natural supplementation plan. (DO NOT TAKE ANY NATURAL AMINO SUPPLIMENT IF YOU ARE TAKING MAOI!!!) Weeks off of the drug must pass first. I cannot stress that enough!

I'm only posting this info because, while it took some time and I had to study a lot to get it right, I'm actually free from AD meds and feeling better than ever. In fact I can even tell this feels sustainable and will continue to work because it addressed the chemical deficiency of Norephineperine in my brain, Rather than trying to squeeze more toothpaste out of an empty tube using meds. Prior to this my next suggested route was ECT. (I'm not against that, but I wanted to avoid ECT and for many good reasons.) TMS was not an option because most Insurance companies will not cover TMS, so unless your wealthy TMS is not an option for most people.

Below is just some basic MD info that I first used to steer me toward my current therapy. I figure at the least it may be a good starting point for others as it was for me:

With depression and mood disorders rising to epidemic levels, we need to move beyond the initial treatment options of psychiatry, namely medication, and embrace a more natural and complete treatment approach. Whether someone is clinically depressed or has a bad case of the blues, the keys are two neurotransmitters, namely norepinephrine and serotonin.
Mainstream medicine has lost sight of the fact that nutrients in our diet are the precursors of neurotransmitters, just as nutrients make up 100% of the body. Amino acids are the precursors to every neurotransmitter, with the exception of acetylcholine.
There are several ways to test for neurotransmitters to find out which ones are deficient, and which ones are causing a person’s feeling of depression. We’ll get to lab testing later. Medicine and psychiatry have assumed that serotonin is the main problem in depression, and so their first treatment approach is with an SSRI antidepressant (like Prozac, Paxil and Zoloft) to raise serotonin levels. After testing people for neurotransmitters since 1982, I’ve found that at least 65% of depressed people are deficient in norepinephrine and not serotonin. Some depressed people are deficient in serotonin and some are deficient in both norepinephrine and serotonin.
How can you tell if your feeling of depression or the blues is a serotonin or norepinephrine problem? When norepinephrine is deficient, the person will feel depressed, and generally has an array of cognitive problems, such as decreased memory and concentration, brain fog, indecision, irritability, increased worry, anger, and insomnia.
Serotonin deficiency is associated with depressed mood and insomnia. There can be some cognitive problems, but they are much less frequent and intense than in norepinephrine-related depression.
Which Natural Way To Turn?
Let’s say you’re feeling depressed due to a serotonin deficiency, and you want a natural approach (or you want a natural approach to help you get off medications). Do you supplement with St. John’s Wort, SAMe (S-adenosyl methionine), L-tryptophan, 5-HTP (5-hydroxy-tryptophan), omega-3 fatty acids, or magnesium?
Before exploring which approach to take, let’s look at the biochemistry. The amino acid L-tyrosine enters the brain and is converted into the neurotransmitter dopamine, which then converts into norepinephrine. For an adult, 1000 mg of L-tyrosine twice a day will bring results. Tyrosine must be taken 45 to 60 minutes before or after breakfast and lunch. Protein is made up entirely of amino acids, and several amino acids will compete with tyrosine to cross the blood-brain barrier to get into the brain.
L-tyrosine requires pyridoxal-5-phosphate, P-5-P, to get converted into norepinephrine. P-5-P is the active form of vitamin B6, pyridoxine, and must be taken as an enteric-coated capsule. If you purchase P-5-P in a capsule, it will do little good, for it will be broken down by stomach acids and rendered useless.
The biochemistry that increases serotonin is similar to that of norepinephrine. The amino acid L-tryptophan, on an empty stomach, enters the brain, and in the presence of P-5-P, gets converted into 5-HTP and then serotonin. There is no controversy about whether L-tryptophan turns into serotonin, but there is debate about the efficacy of 5-HTP, which is unpredictable in getting into the brain.
The simple equation is this: L-tyrosine, in the presence of P-5-P, increases norepinephrine brain levels. L-tryptophan, in the presence of P-5-P, increases brain

serotonin levels. The total biochemistry is a long chain of events in which a weakness in any part of that chain will interfere with the goal of increasing a deficient neurotransmitter.
In addition to L-tyrosine and L-tryptophan, other amino acids are implicated in mood. A study of 500 depressed people revealed a deficiency in the amino acid L-glutamine in 50% of the subjects.
Lab Testing
The most important lab test for depression is amino acid analysis. Amino acids, like L-tyrosine and L-tryptophan, are the “input” side to brain chemistry. Because almost all neurotransmitters are made from amino acids, treatment with amino acids is the first step in a natural approach.
The second important lab test is for urine organic acids. These are the breakdown products of 40+ important biochemical processes. This is the “output” side of brain chemistry. The organic acid test includes testing for the breakdown products of catecholamines (norepinephrine and dopamine) and serotonin. If your VMA (from organic acid testing) is quite low, I know that you are deficient in norepinephrine. On the other hand, if your 5-HIAA (5-hydroxy-indolacetic acid) is low, you’re deficient in serotonin.
Let’s look at how to understand the lab work. On amino acid testing, if L-tyrosine is low, chances are extremely high that you are deficient in norepinephrine, but I’ll want to look at the results of organic acid testing for confirmation. If L-tyrosine is low, VMA, the breakdown product of norepinephrine, is usually deficient.
Similarly, on amino acid testing, if L-tryptophan is deficient, chances are very high that you are deficient in serotonin, but I’ll want to confirm that with the organic acid test. If 5-HIAA, the breakdown product of serotonin, is deficient, you have a serotonin deficiency.
There’s a mathematical equation that tells us the likelihood of L-tyrosine or L-tryptophan working. To find out if L-tyrosine will work, taking the numerical values from the test, divide L-tyrosine by the denominator, which is leucine plus isoleucine plus valine plus phenylalanine plus tryptophan. If that number is .15 or less, chances are 80% that you will have a good response to treatment with L-tyrosine. A similar equation exists to predict the response to treatment with L-tryptophan. The science of treating depression by normalizing the brain’s nutritional deficiencies has been established for more than 40 years.
The lab I use for amino acid and organic acid testing is Genova Labs. On occasion I’ll use Vitamin Diagnostics Lab, in New Jersey, to test for more than 10 different neurotransmitters. Their testing is based on research that has shown that the levels of neurotransmitters in blood platelets correlates strongly with brain levels of those neurotransmitters. I’ll go this route if I think someone might be deficient in acetylcholine, the lack of which causes severe memory problems and a feeling as if someone pulled the plug on mental energy.
Links in the Chain
The response to amino acid therapy depends on the weakest link in a chain of events. First, it’s important to identify and treat any problems with digestion and absorption from the gut. If the digestive tract is not running at 100%, absorption of nutrients declines.
B vitamins are essential for this biochemistry. Nearly every B vitamin plays a role in brain chemistry, the most important ones being biotin, folic acid, P-5-P, and B12. So
supplement with a multi-B vitamin. Vitamin C is also important, and is critical for the production of serotonin, norepinephrine, and for adrenal function.
Minerals also play a role, the most important ones for neurotransmitters being magnesium, zinc, copper, and iron. Magnesium is the most important mineral for amino acid chemistry. If you’re depressed and feeling agitated, or fatigued, apathetic and slowed down, you are likely to have a magnesium deficiency.

Many people ask why L-tyrosine is recommended to raise norepinephrine levels, instead of using the amino acid L-phenylalanine. Phenylalanine turns into L-tyrosine and will raise norepinephrine levels, but one should first go the L-tyrosine route, along with the needed cofactors, for a couple of months. If you are still depressed, or improving but still have a way to go, then add L-phenylalanine. Phenylalanine can raise blood pressure, so it’s not a first line treatment.
Let’s summarize the initial supplements for treating depression:
1) L-tyrosine, L-tryptophan or both - depending on what the lab data indicates. 2) P-5-P, 3) B complex, 4) multivitamin, 5) multi-mineral, 6) magnesium, which needs to be taken with calcium to keep the two in balance, 7) Vitamin C, and 8) sublingual B12.
The Anxiety-Depression Connection
Many depressed people also feel anxious. For many people, correcting norepinephrine and serotonin will alleviate depression and anxiety. However, if anxiety persists, supplementing with GABA, up to 4 grams a day, is recommended. If GABA is helping you, do not think that more is better. At high doses GABA produces anxiety, rather than alleviating it.
In treating depression with or without anxiety, there are a number of issues, beyond the normal biochemistry, to look at: 1) Sugar depletes B vitamins; 2) Nicotine depletes vitamins A, C, E, and B. It decreases vitamin C by 50%; 3) Caffeine stimulates the release of norepinephrine, but in the process depletes the brain of L-tyrosine, the precursor to norepinephrine; 4) Long-term excessive alcohol use can deplete almost all neurotransmitters, including norepinephrine, serotonin, GABA, and acetylcholine. Alcohol abuse will lead to depression. Alcohol treatment involves repairing all neurotransmitters, but GABA depletion is the lynch pin.
A final consideration involves antidepressant medications. SSRIs (Paxil, etc) increase serotonin levels but, in the process, deplete the brain of L-tryptophan, which is stored in nerve endings. Bupropion (Wellbutrin), an antidepressant that increases norepinephrine levels, depletes the brain of its stores of L-tyrosine. As a result, these medications often start to lose their efficacy after many months. The usual psychiatric recommendation is to increase the dosage of that medication, rather than to supplement with the depleted amino acids.
Optimal Mind
In this series we’ve looked at conventional treatments for mood, such as medications, as well as natural ways of bringing the brain to an optimal level. A total approach also includes looking at our relationships, stressors, unresolved conflict, spiritual connection, and sense of purpose. If life is a horse and carriage, our sense of purpose is the horse, and its power will just pull our life forward automatically. Without a sense of purpose, our life is only the carriage. In that situation it takes a great deal of effort to get going, to feel happy, and motivated. While we don’t all have a clear sense of purpose, Wayne Dyer has explained that, for some, beginning to inquire about one’s purpose ——is one’s purpose. So, don’t wait to get that horse in place. My goal is to empower people by helping them develop a healthy brain, a peaceful and powerful mind, a spiritual connection, and a sense of purpose. With that holistic approach to life, people can go way beyond limiting thoughts about their potential for healing, success, and happiness.

[healingme4me]

Thanks for sharing. Sounds like quite a lifetime of trial and error to find something that works, for you.