[hyggelig]

Antidepressant drugs may produce a persistent physiological adaptation over time that manifests as progressive tolerance, and this eventual loss of effectiveness may result from repeated antidepressant administration per se.1 Might Antidepressants Create Treatment Resistance? | Psychiatric Times

I was told the loss of efficacy of antidepressants over time may be problematical. Now there is evidence, "It’s the antidepressants themselves: it is possible that we are creating treatment resistance with each repeated trial?"

[Sunflower123]

Great article. Option A sounds like me. I've tried so many, I feel like I've tried them all and my body has become resistant. Thanks for sharing.