[metamorphosis12]

A nice little paper on SAM-e. I have used it at 400 mg for about two months and I definitely noticed a difference in my mood. It is just a very expensive supplement to use at a therapeutic dose! I will start using it again soon. It's benefits not only to the mind but to entire body are exceptional!
Clinical Considerations for SAM-e Use in Helping to Support a Healthy Mood

Some other benefits:

S-adenosylmethionine
Overview
S-Adenosylmethionine (SAMe) is a naturally occurring compound that is found in almost every tissue and fluid in the body. It is involved in many important processes. SAMe plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. It works with vitamin B12 and folate (vitamin B9). Being deficient in either vitamin B12 or folate may reduce levels of SAMe in your body.
Numerous scientific studies have shown that SAMe helps relieve the pain of osteoarthritis, and other studies suggest that SAMe may help treat depression. Researchers have also examined SAMe's use in the treatment of fibromyalgia and liver disease, with mixed results. Many of the early studies used SAMe given intravenously or as an injection. Only recently have researchers been able to look at the effects of SAMe taken by mouth.University of Maryland Medical Center

from:
S-adenosylmethionine | University of Maryland Medical Center

A scientific paper on SAM-e
S-Adenosyl-l-methionine (SAMe): from the bench to the bedside?molecular basis of a pleiotrophic molecule

http://www.journal-of-hepatology.eu/...409-6/fulltext



more links:
SAM-e - National Institutes of Health Search Results

S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. [ISRCTN36233495]

Physicians Postgraduate Press, Inc. - Login

[nummy]

Interesting, but I'm on Abilify and heard this stuff interacts with some psych meds?

[metamorphosis12]

Originally Posted by nummy

Interesting, but I'm on Abilify and heard this stuff interacts with some psych meds?

Yes, it can. So you have to be careful and converse with your docs or knowledgeable pdocs about it!
These are from medscape. The first is it's use and dosing. The second is the drug interaction checker. Even though it may say the drug and SAM-e are okay. Talk to your doc or pdoc, hopefully they have a clue. My pdoc actually recommended it to me. If you wan't .You can always print out what you have from reputable internet sources. I just googled med. interactions with SAM-e. You can actually get more info by narrowing it down to Abilify and SAM-e. I don't know if you want to go as far as trying to find studies. Ummm, I think that would take a long time and effort but you just go in with what you have and ask them. Knowledge is power and a great help for your own health!
http://reference.medscape.com/drug/a...-same-344548#0
Medscape: Medscape Access