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  #1  
Old Jun 13, 2012, 11:42 AM
constantlyseeking constantlyseeking is offline
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Member Since: Jun 2012
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Hi All.
I was taking 450 mg of Buproprion for about 2 years or more and my depression got a LOT better. I started to notice that I would get the sinking, falling, brain zap-like feeling about 6-8 hours after taking the meds. It was extremely uncomfortable and distracting to the point that I had to cut back to 300 mg. The "zaps" were not as severe but still very much there. So, I started to take the pills about an hour or 2 before bed so that I would be asleep when the symptoms started. This seemed to be working except the depression crept back in. I added Lexapro and soon after the generic for it and started experiencing all kinds of side effects and had to come off it. So now I am in the withdrawal phase of that. I would really like to find a way to tolerate the Buproprion at 450mg as that seemed to work best. Any research I've done on the "zaps" only talk about them in relation to withdrawal but I had them while on the med.
Any advice?

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  #2  
Old Jun 15, 2012, 10:40 AM
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Taonuviel Taonuviel is offline
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Location: Michigan
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So you're saying you were on 300mg when you tried taking it before bed, but didn't try that with the 450mg? Maybe the extra dosage would be enough to fight back the depression.
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  #3  
Old Jun 15, 2012, 08:19 PM
o.kay o.kay is offline
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I first took bupropion over 10 years ago. At first I took 300mg. Eventually that stopped working. I went up to 450mg and tolerated that for about a year. I had great results from bupropion for all those years. But then about 6 months ago I felt like I had a constant buzz in my head(don't know how else to explain it). Went back down to 300mg which isn't working. I'm now going down to 150mg and adding viibryd. so far so good. keeping my fingers crossed.
  #4  
Old Jun 16, 2012, 07:23 AM
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Fresia Fresia is offline
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I noticed this happening more when I took the higher dosage all at once as opposed to dividing the dose up. I will take it first thing in the a.m. and later in late afternoon. It seemed to lessen the brain "zaps" or "fog" as I would call it. This seemed to help with that side effect and keep the depression at bay.
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  #5  
Old Jun 17, 2012, 09:44 PM
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ickydog2006 ickydog2006 is offline
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I don't do well with taking meds at night (makes them way less effective for me), but splitting the doses throughout the day can be really helpful.
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  #6  
Old Jun 20, 2012, 01:12 AM
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sugahorse1 sugahorse1 is offline
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I've just gone from 150mg to 300mg which I take in the AM. About an hour after I've taken them, my brain starts to feel very foggy and I battle to do much at all
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