[Teanne]

My pdoc has me on Wellbutrin (300 mg) and Seroquel (100 mg). A friend told me that these are two strange drugs to be on because they are both really add-on drugs when your regular antidepressant isn't enough.

I can't say that I feel good, because I have treatment-resistant major depression. It is hard for me to get up each morning, and everything that I do seems like it takes so much effort. I cry very easily. I'm thinking I should be on another antidepressant also. I used to be, but my pdoc doesn't like her patients to be on too many drugs. She even wants to cut my Seroquel to 50 mg.

I'm not sure what I am asking. What has been your experience with taking just add-on antidepressants? What is your opinion of not being on a general antidepressant? Thanks so much for any help!

[*Laurie*]

As I understand it Wellbutrin is an anti-depressant, not an adjunct medication.

Seroquel is an anti-psychotic. In low doses it is used to help sleep. For some people Seroquel has an anti-anxiety or anti-depressant effect. For me it does not.

[Teanne]

Originally Posted by *Laurie*

As I understand it Wellbutrin is an anti-depressant, not an adjunct medication.

Seroquel is an anti-psychotic. In low doses it is used to help sleep. For some people Seroquel has an anti-anxiety or anti-depressant effect. For me it does not.

Thank you, Laurie. That is interesting. My pdoc told me that they were both used as add-on antidepressants and to let her know if I was feeling depressed, as she would then start me back on a regular antidepressant also.

Interesting the way different doctors explain things. It's kind of like research...they all interpret that differently also.

[*Laurie*]

Yes, it seems that every pdoc has a different approach to medication, sometimes vastly different. It's frustrating sometimes.

[TicTacGo]

Yeah, from what I understand, Seroquel can be used in conjunction with an antidepressant for depression.
In bipolar patients it is often used in conjunction with mood stabilizers such as lithium, both displaying antimanic properties and lithium significantly decreasing the risk of suicide.

[VanGore28]

Seroquel is my most important med for schizoaffective and yes it does help with depression but can take a while to get used to. Its got a good deal of sedative in it so rising in morning will be more difficult I'd guess. You may need something else in conjunction that targets just depression. Lithium works for me , I only stopped because my nurse said it was a salt that damaged the liver so I stuck to mirtazapine and venlafaxine (known as CALIFORNIAN ROCKET FUEL supposodely lol) they don't do that much for me.

But take your concern to your doctor. Mine doesn't believe in too much medication , VERY strange for a psychiatrist not trusting his chosen field?? so I self medicate because I'm not content with the docs in my area. I don't recommend this obviously