Bupropion hcl 150mg xL question?

My doctor prescribed Burpropion HCL 150mg XL last week, but I did *exactly* what you're not supposed to do and went online to read about possible weight gain/loss and it seems like a lot of people lost and gained on it.

I was heavy growing up and was bullied a lot for years on end for it and I am terrified it will make me gain the weight back that I worked so hard to lose over the years. My doctor says it's the least likely antidepressant to do that.

Anyone had any experience with weight fluctuations on it?

(Mostly a worry because I work 3rd shift and some days I don't get a chance to exercise, but I don't really even eat much now)

Thanks!

I've been told that it is not as likely to cause weight gain as others. I've never been on it myself.

I've taken 450 mg of Bupropion a day for a long time and it hasn't caused weight gain.

I take 150xl and it curbs my appetite. That is until I take my 20mg of zyprexa then its game on...

Hi,

I took Wellbutrin SR for about two years many years ago (from 2003 to 2005, if my memory is serving me correctly), and I didn't notice any changes in my weight in the time I spent taking the medication. The Wellbutrin SR did seem to reduce my appetite some, despite the fact that I didn't notice any changes in my weight one way or another, but after the psychiatrist that I was seeing at the time prescribed me lithium to take along with the Wellbutrin SR at least a few months into my Wellbutrin trial, my appetite seemed to return to a level that was normal for me. Still though, my weight didn't seem to change in any noticeable way in the time that I spent taking Wellbutrin, whether or not I was taking lithium along with the Wellbutrin. I'm not saying that I can be sure that you won't gain weight while taking Wellbutrin simply because I didn't gain weight on the medication, but I did take the medication for two years without any noticeable weight changes, and my understanding about Wellbutrin's potential to affect weight is consistent with your doctor's idea that taking Wellbutrin is less likely to lead to weight gain than other antidepressants. In fact, there's evidence from a scientific review article (Li et al., 2005) that Wellbutrin can promote modest weight loss. The article, which included an analysis of three studies that examined the effectiveness of Wellbutrin in the treatment of obesity among individuals who had major depressive disorder or depressive symptoms found that those who took Wellbutrin lost an average of 2.77 kg (6.1 pounds) more than those who took a placebo over a period of 6 to 12 months. So, I'm not saying that it's impossible to gain weight on Wellbutrin, but losing weight on Wellbutrin seems to be more likely than gaining weight on the medication, judging from what I've read.

I wish you luck with taking Wellbutrin, assuming that you're already taking it or will go ahead with taking it soon.

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REFERENCE

Li, Z., Maglione, M., Tu, W., Mojica, W., Arterburn, D., Shugarman, L.R., et al. (2005). Meta-analysis: Pharmacologic treatment of Obesity. Annals of Internal Medicine, 142, 532-546. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15809465

Back when I was on Wellbutrin XL, I lost weight. It was one of the most appetite suppressing meds I've ever been on.

Been taking Buproprion 150 SR for the last few years or so and have not had any weight gain.

Sorry if this posts shows up a few times. Doesn't seem to be working with my iPad. I have taken Buproprion SR 150mg for a few years with no major changes in weight. Good luck to you.

Thank you to everyone who took time to reply. I figure I will give it a shot.

hi. wellbutrin doesn't usually cause weight gain, some people even lose weight. having said that, if you're on additional drugs, my own experience has been that drug-drug interactions can make things...unpredictable. your doctor should take that into account, of course. still, it wouldn't hurt to do one of those free, online, drugs interactions checkers. they don't pick up on everything, but they seem good about alerting people to more potentially dangerous combinations.

Anyone ever experienced a constant dilation in their eyes? Mine are big & small, almost like a pulse.

I take zoloft 200 and wellbutrin xl 450 and have been taking both for about 2 years. I've lost about 70 lbs over that time. Granted, I was also trying to watch what I was eating, but not super strictly. Good luck.