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  #1  
Old Oct 18, 2019, 08:51 AM
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Calla lily12 Calla lily12 is offline
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Has anyone been prescribed this for treatment resistant depression? It may come under other names, but I don't know them. I'd be interested in hearing any experiences, good or bad.
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  #2  
Old Oct 18, 2019, 09:01 AM
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sarahsweets sarahsweets is offline
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Hey @Calla lily12 Here is something interesting I found:
Quote:
The Psychiatry Advisor take:
Buprenorphine, a medication used in the treatment of opioid addiction, may also benefit patients with treatment-resistant depression, who have not responded to antidepressants, researchers found.

Jordan F. Karp, MD, of the University of Pittsburgh School of Medicine in Pennsylvania, and colleagues assessed whether buprenorphine improved symptoms in 50 patients with treatment-resistant depression (TRD aged 50 years and older. Participants were prescribed titrated doses of buprenorphine (0.2–1.6 mg/d) during an eight-week period.

Changes in depression, anxiety, sleep, positive and negative effect, and quality of life were assessed. The Montgomery-Asberg Depression Rating Scale (MADRS) served as the main outcome measure.

Mean depression score (MADRS) at baseline was 27.0 versus 9.5 at week eight. A sharp decline in depression severity occurred during the first three weeks of buprenorphine exposure (mean change = −15.0), the researchers reported in the Journal of Clinical Psychiatry.

In addition, depression-specific items measuring pessimism and sadness indicated improvement during exposure, supporting a true antidepressant effect. Also, executive function and learning improved during treatment.

“Low-dose buprenorphine may be a novel-mechanism medication that provides a rapid and sustained improvement for older adults with TRD,” the researchers concluded.
Buprenorphine Improved Resistant Depression Outcomes - Psychiatry Advisor
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Originally Posted by Calla lily12 View Post
Has anyone been prescribed this for treatment resistant depression? It may come under other names, but I don't know them. I'd be interested in hearing any experiences, good or bad.
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  #3  
Old Oct 18, 2019, 08:46 PM
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I was on it for a little over a year. I don't think it did much for me, but this was at a time when I was unbelievably sick and quite unstable.
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Old Oct 23, 2019, 10:08 AM
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I take Suboxone for anxiety/depression and it has really helped me.
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  #5  
Old Apr 30, 2025, 06:43 PM
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My doctor looked into it but for some reason it could be dangerous for me.
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  #6  
Old May 19, 2025, 02:58 PM
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Thanks for the info sarahsweets.
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