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#61
remeron (mirtazapine) and seroquel (quetiapine) are working well for me, better than any others have.
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boomerango
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Member Since Mar 2015
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#62
Hello do any of you guys have constant headaches with your dep/anx ?
And sort head twinges ? |
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Location: HOUSTON
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#63
Hello Hunny!
Based on the title of your post, I was eager to open the thread and find out how I too, struggle from short term relief of medications. (some of them only last for 2 months.) If I read your post in its entirety, I was hoping to hear a combination of medicines that helps with treatment resistant depression |
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#64
I started Topamax for migraine and increased my dose to 75 mg about a week ago. Over the past several days my mood has definitely improved to where I'm feeling close to normal I think! Imagine that! Can't say for sure, but I'm really wondering if it can be attributed to the Topamax, which I know is used as a mood stabilizer.
As much as this past week was dreadful with the fatigue of adjusting to the increased dose, if that's what it took to get to this improved mood (maybe a little hyper I daresay), so be it! This has been about 2 or so years since I've felt halfway decent. I full well deserve to be happy and live a life like most/many others on this planet! Here's wishing those of you still suffering from this horrible disease experience a turnaround in your mood really soon. |
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#65
I'm happy for you newgal. It's great that your mood is lifting. Remember this moment if it gets bad again: it IS possible for you to feel better.
And you're right: you do deserve to feel happy and live your life. |
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Member Since May 2015
Location: Greenville, NH
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#66
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boomerango
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Magnate
Member Since Apr 2015
Location: Canada
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#67
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Member Since Apr 2015
Location: Indianapolis, IN
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#68
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Dear HunnyRose, I don't even know if I am doing this right. My response seems to just be an addition to your post. I'm going to end this and see what happens but I wanted you to know that you are not alone! I just feel like screw this life crap almost every day but I don't want to die, I want to not be so depressed that I just feel like I"m going through the motions everyday. My inability to pull my s*** together because I feel like I have cement in my brain and it doesn't seem to want to work (my brain). I just feel in slow motion and I HATE it and I get very anger too to the point where I am bawling and sometimes throw things or hit things. I know it sounds and that I am acting immature but gawd, it makes me so mad bc I feel like my life is just passing me by and that life acts on me vs me acting on life. I've been on almost all the antidepressants and several of the atypical anti psychotic meds. I got restless leg syndrome from something and my RLS is more like involuntary movement stuff - like my legs and arms will kick out and if I don't have Mirapex, I have literally gone into convulsions. it's awful. And my shrink (who's awesome) wants me off the Mirapex because it's been proven to increase impulsivity(huge issue for me) as well as affecting other cognitive functions. I was like "are you kidding me?" and Im having super trouble getting off of it. Man, I've just gone on and one. So many people don't get it though because it doesn't show and I can smile and laugh and fake everyone out bc they don't get it anyway. |
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#69
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Member Since Jul 2015
Location: Wentworth, Mo
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#70
One common treatment for doctors sometimes for treatment resistant are MAOI medications. It's an older class of medicine and works differently than SSRIs or anything other antidepressant as far I know. MAOIs, Monoamine-Oxidase Inhibitors work by decreasing MAO, which stands for Monoamine-Oxidase. Don't quote me on this I'm no doctor but this is how my psychiatrist explained it to me. Basically, MAO is an enzyme that the brain activates that breaks down nor epinephrine, serotonin and dopamine So some people with depression may not have less serotonin but actually too much MAO being produced and that can cause depression too. One of these MAOI's is called Nardil and has been pretty good for me for the depression, Still not sure if it's best for me.
One other thing I wanted to mention is that there is a supplement called DHA, which is a type of fish oil which studies have shown to really help mood and One of the major building blocks of the brain, the omega-3 fatty acid docosahexaenoic acid (DHA) is critical for optimal brain health and function at all ages of life. Researchers are now finding that DHA provides brain-boosting benefits. I've been taking it for 6 months now and it has made a big difference in my life __________________ "Will I take on challenges as an opportunity to become better or will I let my Insecurities prevent me from overcoming challenges in my life?" "It is not our abilities that make us who we are, but our choices"- Albus Dumbledore |
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Member Since Aug 2015
Location: Illinois
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#71
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Yours_Truly
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#72
you sound like a kindred spirit- but of course it isn't politically correct to say these things out loud. thanks for making me smile today.
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Member Since Jul 2015
Location: Memphis
Posts: 84
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#73
Well, that remark (below) did get me laughing. A dark humor kind of laugh.
Until recently (last couple of years; age 58), I have been depressed and on many different meds. What happened to me? I tend to think that I was suddenly able to see life on this planet and in this universe as it really is. That is, that the overwhelming majority of people "may" indeed have some sort of delusional gift especially when it comes to believing in an perfect afterlife, a God, angels, etc. Perhaps in order to humankind to survive they need these possible delusions and brain chemistry (serotonin and certain pathways, same with the other neurotransmittors) is hardwired in a certain way to make these possible delusions. Wish I still had them (possible delusions) and the possible hardwired brain chemistry. At least I would be happy. I am trying hard to focus on just how profound this universe is (universes within universes, string theory, simply the profundity of the night time sky) and keep in mind that that anything is possible...the delusions of these people "may" not be delusions after all. Any way you twist and turn it, we are having a way out experience. Trying hard not to forget that and that I should feel somehow fortunate despite all the pain that surrounds me. Perhaps to see this more clearly, we need to "enlarge the borders" of our mind. Take care, my friend. Anna, "preaching" to herself, I reckon. QUOTE=hunnyrose;4003489] Seems like the main thing "non-depressed" people have going for them is some kind of delusional gift for pretending things are better than they are.[/QUOTE] |
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#74
I have major suicidal ideation with attempts, which are the hallmarks of my treatment resistant depression. I take effexor xr, welbutrin xl, abilify, seroquel for sleep and klonopin for anxiety. That has been my med routine for the past 16 years and it has worked somewhat. But now I have added ECT every 2 weeks, and will be adding a low dose of clozaril. TRD is the pits!!!
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Yours_Truly
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Member Since Jul 2015
Location: Memphis
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#75
It is the pits.
Curious to know if anyone here--new to the forum TRD--has gone the L methyl folate route? Anna Quote:
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Member Since Jun 2016
Location: New Hampshire
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#76
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Yes. But I'm a newbie so no insight yet. Just got genetic testing done and I have the particular gene series that indicates that I need L methyl folate supplements basically for the rest of my life. I started Deplin 4 days ago and am trying to be cautiously hopeful, as I have tried pretty much everything else medication wise to no avail. I'm also entering a ketamine trial next month so hopefully one, the other, or both will finally give me some relief. __________________ “For a seed to achieve its greatest expression, it must come completely undone. The shell cracks, its insides come out and everything changes. To someone who doesn't understand growth, it would look like complete destruction.” ― Cynthia Occelli |
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boomerango
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boomerango
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Member Since Apr 2014
Location: Canada
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#77
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They are studying it actually. The drug company Alkermes has something they've been working on that I've been watching, tentatively called alks5461. It was given fast track status by FDA but it's still might be a while & still faces hurdles. It's supposedly designed to block the addictive properties via mu receptor. There was an article in the NYTimes a couple weeks ago about opioids for depression; naturally occurring, how some may be 'low' just like serotonin. Sent from my iPhone using Tapatalk |
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Member Since Oct 2015
Location: Pittsburgh, PA
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#78
I have been on SSRI's and SNRI's for about 25 years and a lifetime of depression. I have had about 3 major depressive episodes and I am currently in the third. I am starting ECT next week. I have to do something b/c I don't want to get out of bed or leave the house.
In terms of medication the miracle for me was stimulants. I became the person I always wanted to be. I had lots of energy, lost weight, and was very social. Problem.....I kept needing more and more to maintain the transformation. I am an alcoholic and began to feel addicted to stimulants (Adderall). When coming off of the stimulant I would feel a crash. So, I told my doctor and stopped stimulants after two years and crashed BIG time. So now ECT then back on some kind of med for depression then hopefully I can function and return to work. Sucks |
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Member Since Jul 2016
Location: Houston
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#79
What kind of stimulant?
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