Meds that work for me for treatment resistant depression

Yes. But I'm a newbie so no insight yet. Just got genetic testing done and I have the particular gene series that indicates that I need L methyl folate supplements basically for the rest of my life. I started Deplin 4 days ago and am trying to be cautiously hopeful, as I have tried pretty much everything else medication wise to no avail. I'm also entering a ketamine trial next month so hopefully one, the other, or both will finally give me some relief.

They are studying it actually. The drug company Alkermes has something they've been working on that I've been watching, tentatively called alks5461. It was given fast track status by FDA but it's still might be a while & still faces hurdles. It's supposedly designed to block the addictive properties via mu receptor. There was an article in the NYTimes a couple weeks ago about opioids for depression; naturally occurring, how some may be 'low' just like serotonin.


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I have been on SSRI's and SNRI's for about 25 years and a lifetime of depression. I have had about 3 major depressive episodes and I am currently in the third. I am starting ECT next week. I have to do something b/c I don't want to get out of bed or leave the house.
In terms of medication the miracle for me was stimulants. I became the person I always wanted to be. I had lots of energy, lost weight, and was very social. Problem.....I kept needing more and more to maintain the transformation. I am an alcoholic and began to feel addicted to stimulants (Adderall). When coming off of the stimulant I would feel a crash. So, I told my doctor and stopped stimulants after two years and crashed BIG time.
So now ECT then back on some kind of med for depression then hopefully I can function and return to work.
Sucks

What kind of stimulant?

Thanks