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#1
Dec 11, 2014, 05:50 PM
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www.medscape.com
Antipsychotic Linked to Potentially Fatal Skin Reaction Caroline Cassels December 11, 2014 The antipsychotic ziprasidone (Geodon, Pfizer Inc) and its generic counterparts have been linked to a rare but potentially fatal skin reaction, prompting the US Food and Drug Administration (FDA) to add a new warning to the drug's label. Known as DRESS (drug reaction with eosinophilia and systemic syndromes), this serious condition can start with a fever and a rash and/or swollen lymph glands. DRESS can quickly spread to all parts of the body, causing inflammation in major organs, including the liver, kidneys, lungs, heart, or pancreas. DRESS can also increase eosinophils and lead to death. Ziprasidone is used to treat schizophrenia and bipolar I disorder. At the first sign of fever and rash, patients should seek immediate and urgent medical care, the FDA notes in a release. In addition, healthcare professionals should immediately stop treatment with ziprasidone if DRESS is suspected, but it also warns that patients should not discontinue the drug on their own, particularly in the absence of symptoms. The FDA warning is based on a review of six patients in whom the signs and symptoms of DRESS appeared between 11 and 30 days after initiation of ziprasidone treatment. None of the patients died. The FDA has required the drug's manufacturer to add a new warning for DRESS to the Warnings and Precautions section of the drug labels for the capsule, oral suspension, and injection formulations. The FDA is urging healthcare professionals and patients to report side effects involving ziprasidone to the FDA MedWatch program at 1-800-332-1088 (P), 1-800-FDA-0178 (F), or MedWatch Online. Medscape Medical News © WebMD, LLC Heartwire © WebMD, LLC WebMD Health News © WebMD, LLC Reuters Health Information © Send comments and news tips to news@medscape.net. Cite this article: Antipsychotic Linked to Potentially Fatal Skin Reaction. Medscape. Dec 11, 2014. |
 jelly-bean, Takeshi, wing
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#2
Dec 11, 2014, 07:20 PM
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Thank you for bringing this to everyone's attention! This is a very serious matter for many of the members here.
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| wing
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#3
Dec 11, 2014, 08:51 PM
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I'm on Geodon and have been for almost 2 years. Good to know this information though.
__________________
DX: Bipolar 1 Anxiety Tardive dyskinesia Mild cognitive impairment RX: Celexa 20 mg Gabapentin 1200 mg Geodon 40 mg AM, 60 mg PM Klonopin 0.5 mg PRN Lamictal 500 mg Levothyroxine 125 mcg (rx'd for depression) Trazodone 150 mg Zyprexa 7.5 mg Please come visit me @ http://bpnurse.com |
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#4
Dec 11, 2014, 09:24 PM
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Just for shytes and giggles :
Surgeon General Warning : Being Alive Is Dangerous To Your Health |
| BipolaRNurse, wing
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#5
Dec 12, 2014, 04:54 AM
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I broke out in hives after about 11 or 12 days on Geodon in 2010. I went to the local ER and they stabilized me.
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#6
Dec 12, 2014, 02:28 PM
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I've been on Geodon for four years. I'm so glad I didn't have an adverse reaction because it has been a lifesaver (literally) for me.
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"What people are ashamed of usually makes a good story." -F. Scott Fitzgerald BP1, ADD, GAD Geodon-100mgs Cogentin-1mg Pristiq-50mgs Lamictal-100mgs Wellbutrin-300mgs Strattera-80mgs Valium-10mgs PRN Xanax-1 mg PRN Ambien-10mgs PRN |
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