I am generally an irritable person, but I've learned to control my behavior rather well (i.e., I don't scream "shut up!" at the person in the coffee shop tapping their pencil on the table, even if I think they deserve it .

However, over the past 3 days I've had a series of angry outbursts and I'm worried this may mean zoloft is causing me problems (increased from 25 to 50 about 2 weeks ago). It sort of feels like really bad PMS...very quick to anger, feeling emotionally overwhelmed, crying, picking fights, impulsive lashing out via text etc. I've been able to calm myself down after each outburst but have already said/done things I regret.

Maybe I'm overreacting. Maybe this is a 'normal' response to adjusting to the dose. I don't know...I guess I'm just looking for some objective input.

[JustJace2u]

Have you talked to your pdoc about this?

Zoloft may be causing you problems, but you also have to look into your mood stabilizers. Maybe your mood stabilizers aren't at high enough dosages, or maybe you just can't tolerate Zoloft. That's something your pdoc is going to have to figure out.

If you really like Zoloft in general, then I recommend asking about increasing your mood stabilizers first.

But for what it's worth, I used to be severely pissed off 100% of the time. Then when my Lamictal dosage was increased from 200mg to 300mg, the irritability/anger went away.

I'm not on any mood stabilizers...only zoloft, which is partly why I'm nervous. I'm also nervous to tell my pdoc because I'm afraid of switching/adding meds (not entirely rational, I know).

Once I feel better I feel like "oh, that was just a weird glitch" and am fine. But then it happens again. But maybe it's just stress??

[Spaceyspace]

It got worse for me when I was given 10mg of Prozac once. I seem to be tolerating 20mg of celexa fine.

Prozac did this for me. If you've already done things you regret, and you are worried you will repeat this, definately talk to your doctor ASAP. I relate to everything you wrote, about fear of adding meds. This sounds like a med reaction and doing things you regret is not acceptable. (((Hugs)))

[Gabyunbound]

I'm really sorry you're going through this. I absolutely hate it when I've done something that I later regret and then I feel like there's just no turning back. Though is it possible to apologize to at least someone you've lashed out at? It might help to make you feel better.

It's great you've been able to control your irritability until recently, that must have been really hard.

Is it possible that -aside from the higher dose of Zoloft- something has triggered this? Is there anything going on in your life (i.e. stress or upsetting things happening with people close to you) that might of triggered these episodes of anger?

Either way, it looks like you'll need to let your pdoc know about what has been happening -maybe you can give him/her a call? Maybe he'll nix the Zoloft, replace it with something else, or keep it at the lower dose you were on before.

Best of luck to you and I hope you feel better soon!