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Old Jan 12, 2015, 10:50 PM
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I understand there are many possible factors that go into depression and mental illness. I am not trying to debate what came first the chicken or the egg or cause and effect. The issues are very complex.

I do believe that is some percentage of cases of depression there are very strong genetic and biological factors that people are born with. I think with schizophrenia and bi polar I it is more cut and dry for brain structural and functional abnormalities and genetics.

Whatever the causes the best course of treatment is as varied as the possible causes. Biology doesn't mean a med is necessarily the best treatment.

This thread is merely to point out the evidence as it exists. Mainly focused on depression as that is what I have. If you like to read this stuff and read it all you will be very enlightened.

The most compelling theory and evidence to me is structural, functional, synaptogenic, receptor, and communication between the limbic system and pre frontal cortex. Neuron death and shrinkage in the hippocampus. Things messed up in the HPA axis. Cell death in pre frontal cortex. Amagdyla, hypothalamus, thalamus, pituitary, andrenals, etc. Basically a lot going wrong between the limbic system and the pre frontal cortex.

What is very interesting is that it has been shown that antidepressants cause neurogenesis in the hippocampus. Promotion of neurotrophic growth factors, cell proliferation, cell migration and maturity, and differentiation into neurons and glial cells. Synaptogenesis and signaling in the hippocampus and pre frontal cortex.

Knock yourself out if you are so inclined.

Biology of Depression/ Mental Illness
Genetics
JAMA Network | JAMA Psychiatry | A Hospital-Based Twin Register of the Heritability of DSM-IV Unipolar Depression

Stem Cells Reveal How Illness-Linked Genetic Variation Affects Neurons - 08/18/2014

Common Genetic Variation Big Risk Factor for Alcoholism, Mental Illness - Addiction Treatment | Elements | Drug Rehab Treatment Centers

5 Major Mental Illnesses Traced to Same Genetic Variations | Psych Central News

http://www.journalofpsychiatricresea.../abstract?cc=y

NIMH · New Data Reveal Extent of Genetic Overlap Between Major Mental Disorders

Schizophrenia.com - Schizophrenia Genetics and Heredity

GenRED - Major Depression and Genetics - Genetics of Brain Function - Stanford University School of Medicine

Genetic Switch Involved in Depression - NIH Research Matters - National Institutes of Health (NIH)

Depression Research - Psych Central

Genetic link to depression found - Health News - NHS Choices

What causes depression? - Harvard Health Publications

New gene for bipolar disorder discovered -- ScienceDaily

Bipolar Disorder, Genetics, and the Brain :: DNA Learning Center

Schizophrenia and Manic-Depressive Disorder: The Biological Roots of Mental ... - Google Books

Cambridge Journals Online - Psychological Medicine - Abstract - Autism as a strongly genetic disorder: evidence from a British twin study

NIMH · Five Major Mental Disorders Share Genetic Roots

http://www.nature.com/ng/journal/v45...l/ng.2711.html

https://www.nimhgenetics.org/

Genetic Mental Illnesses | DNA and Mental Illness | Psychiatrist in Scottsdale

Mental Illness: The Challenge of Dual Diagnosis

First Blood Test to Diagnose Depression in Adults: Northwestern University News

Clear New Insights into the Genetics of Depression - Scientific American

Massive Study Reveals Schizophrenia's Genetic Roots - Scientific American

Genome Biology | Full text | Hypermethylation in the ZBTB20 gene is associated with major depressive disorder

Translational Psychiatry - How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure

Polymorphism in serotonin transporter gene associated with suscepti... - PubMed - NCBI

Receptor and transporter imaging studies in schizophrenia, depressi... - PubMed - NCBI

Neuropsychopharmacology - Serotonin 1A Receptors, Serotonin Transporter Binding and Serotonin Transporter mRNA Expression in the Brainstem of Depressed Suicide Victims

Animal models of depression in dopamine, serotonin, and norepinephr... - PubMed - NCBI

Influence of 5-HTR2A genetic polymorphisms on the efficacy of antid... - PubMed - NCBI

Genetics and personalized medicine in antidepressant treatment. - PubMed - NCBI

Genetics may bring out the dark side of antidepressants | The Verge

Sundance Diagnostics

http://www.nature.com/neuro/journal/...ll/nn1463.html

http://www.genelogic.com/wp-content/...imbicPaper.pdf

Biology of Depression

Yale Scientific Magazine ? Uncovering the Biology of Depression

The Biology of Depression: How Stress Affects the Brain and the Body - UCTV - University of California Television

http://ajp.psychiatryonline.org/doi/....2009.10030434

http://www.nyng.org/MP%20cytokine%20review.pdf

What causes depression? - Harvard Health Publications

Biology of Depression - Genetics and Imaging - Depression: Major Depression & Unipolar Varieties

http://www.wfsbp.org/fileadmin/user_...Depression.pdf

GenRED - Major Depression and Genetics - Genetics of Brain Function - Stanford University School of Medicine

Unkind Cytokines: A Journey from the Mind to Brain to Mind The Biological Basis of Depression -



Blood test accurately distinguishes depressed patients from healthy controls - Massachusetts General Hospital, Boston, MA

These Are Revolutionary Times for the Biology of Psychology | Psychology Today

http://cdn.intechopen.com/pdfs-wm/22664.pdf

CNS Spectrums: Novel Therapeutics for Depression: L-methylfolate as a Trimonoamine Modulator and Antidepressant-Augmenting Agent

L-Methylfolate: A Promising Therapy for Treatment-Resistant Depression? | Psych Congress Network

Genetic Testing in Clinical Practice: What Psychiatrists Need to Know | Psych Congress Network

The Role and Postulated Biochemical Mechanism of L-Methylfolate Augmentation in Major Depression: A Case-Report | Psychiatric Annals

MTHFR Genotyping Laboratory Genetic Test | Seeking Health

Mice Study Suggests Lack of Serotonin Not Behind Depression | Psych Central News

Neuropsychopharmacology - Ketamine: Promising Path or False Prophecy in the Development of Novel Therapeutics for Mood Disorders[quest]

Neuroimaging of child abuse: a critical review

Immune Suppression and Immune Activation in Depression

Influence of 5-HTR2A genetic polymorphisms on the efficacy of antid... - PubMed - NCBI

Genetics and personalized medicine in antidepressant treatment. - PubMed - NCBI

Genetics may bring out the dark side of antidepressants | The Verge

Sundance Diagnostics

Molecular Psychiatry - Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interactions

http://www.medscape.org/viewarticle/418726

http://rstb.royalsocietypublishing.o.../1633/20130138

http://www.wfsbp.org/fileadmin/user_...Depression.pdf

JAMA Network | JAMA Psychiatry | Brain Serotonin1A Receptor Binding Measured by Positron Emission Tomography With [11C]WAY-100635: Effects of Depression and Antidepressant Treatment

Depression Hippocampus Limbic System and Pre Frontal Cortex

Functional anatomical abnormalities in limbic and prefrontal cortic... - PubMed - NCBI

Hippocampal volume loss in depression reflects glial loss -- ScienceDaily

Alterations of neuroplasticity in depression: the hippocampus and beyond

The Johns Hopkins Psychiatry Newsletter

Depression, antidepressants, and the shrinking hippocampus

https://www.google.com/search?q=depr...Q&ved=0CDYQsAQ

PLOS ONE: Changes in Prefrontal-Limbic Function in Major Depression after 15 Months of Long-Term Psychotherapy

Neurogenesis and antidepressants.

Unraveling the Mystery of How Antidepression Drugs Work - Scientific American

Neuropsychopharmacology - Fluoxetine-Induced Cortical Adult Neurogenesis

Fluoxetine-induced cortical adult neurogenesis. - PubMed - NCBI

Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

The Future of Depression Treatment: The Neurogenesis Theory

Promoting adult hippocampal neurogenesis: a novel strategy for anti... - PubMed - NCBI

The Neural Plasticity Theory of Depression: Assessing the Roles of Adult Neurogenesis and PSA-NCAM within the Hippocampus

Depression

A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor

How antidepressants spur brain growth

http://www.biologicalpsychiatryjourn...581-6/abstract

http://www.cell.com/trends/pharmacol...2814%2900165-5

Depression, antidepressants and new brain cells

Neuropsychopharmacology - Hippocampal Granule Neuron Number and Dentate Gyrus Volume in Antidepressant-Treated and Untreated Major Depression

Implications of adult hippocampal neurogenesis in antidepressant action

http://psychiatryonline.org/doi/full...ajp.160.8.1516

Role of neurotrophic factors in depression

Antidepressants and the immune system

A comparative examination of the anti-inflammatory effects of SSRI ... - PubMed - NCBI

Fluoxetine and citalopram decrease microglial release of glutamate ... - PubMed - NCBI

http://www.rheumatologynews.com/inde...e=98&tx_ttnews[tt_news]=6884&cHash=da03e20e36

A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia. - ResearchGate

Selective serotonin reuptake inhibitors as a novel class of immunosuppressants

Biology of Schizophrenia

The biology of schizophrenia

International team sheds new light on biology underlying schizophrenia | Broad Institute of MIT and Harvard

Biological insights from 108 schizophrenia-associated genetic loci : Nature : Nature Publishing Group

Genes, environment and schizophrenia

Schizophrenia

Patients' own cells yield new insights into the biology of schizophrenia - Salk Institute - News Release

Biology of Bi Polar

Understanding the basic biology of bipolar disorder | UCLA

http://www.ccnl.emory.edu/greg/Bipol...JMG%202003.pdf

The underlying neurobiology of bipolar disorder

YaleNews | Common biology shared in schizophrenia and bipolar disorder

http://bjp.rcpsych.org/content/178/41/s107.full

Mood Disorders Research Program > Psychiatry | Yale School of Medicine

Abnormalities Found in Brains of Young Bipolar Patients Who Try Suicide - MedicineNet

Making sense out of the biological matrix of bipolar disorder -- ScienceDaily

YaleNews | Common biology shared in schizophrenia and bipolar disorder

Bipolar Disorder - Biology Educational Resource | University of Colorado Colorado Springs
__________________
The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

Major Depressive Disorder
Anxiety Disorder with some paranoid delusions thrown in for fun.
Recovering Alcoholic and Addict
Possibly on low end of bi polar spectrum...trying to decide.

Male, 50

Fetzima 80mg
Lamictal 100mg
Remeron 30mg for sleep
Klonopin .5mg twice a day, cutting this back
Thanks for this!
Rose76

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  #2  
Old Jan 13, 2015, 01:32 AM
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It seems to me that a lot of people with psych diagnoses talk as though their sense of self-esteem is highly invested in the notion that their psychological affliction is basically a physiological phenomenon. As Shakespeare put it, methinks "thou doth protest too much." Sure, more than likely there are all kind of genetic/biological vulnerabilities that predispose a person to a mood disorder, or any other psych dysfunction. But why, oh why, is it so awfully important to many people that that should be the case?

I'm not closed to the theory that nature, rather than nurture, may account for a lot, but I'm suspicious of why this gets proclaimed with such passion.

I know why the drug companies want this to be so. I know why psychiatrists want this to be so. I think I know why psych patients want this to be so, and I think it's too bad.

You can take a puppy at random out of just about any litter and turn it into a nice companion, who can lead a pretty joy-filled existence alongside of you. At least, that is generally possible, if you are a person with a reasonable idea of what a doggie needs to have a decent little doggie life . . . and you are able to provide that.

It is also possible to grab any one of that puppy's litter mates, with similar genetic endowment, and turn it into a totally neurotic and miserable little creature. You can make it vicious . . . or nervous . . . or fearful . . . or attention-seeking. Unfortunately, this actually happens quite a bit.

If we see a dog that is a nervous wreck, we don't tend to say, "Gee, I wonder what kind of brain pathology that dog has?" or, "I wonder if his limbic system is wired up okay." Most of us will say, "Gee, I wonder what kind of abuse this dog suffered" . . . . or, "I suppose no one gave this dog any appropriate training" . . . . or, "I guess this dog never got much attention."

I think that what is true of dogs is even more true of humans. Dogs can actually withstand quite a bit of misguided whacking around without turning nasty, or neurotic. The human brain is way more complicated than that of the dog, or any other creature. The modern environment of humans is awfully different from what the human brain evolved to cope with. The human mind is exquisitely sensitive. The potential for the environment in which a human develops to be non-optimal for the best outcome is so huge . . . IMO. I find it amazing that many of us are even the least bit well-adjusted at all.

Then, I look at it in macrocosm. I consider the perversity and depravity of the Third Reich, as a handy example of behavioral pathology on a mass scale. Was biology behind it? I suppose you could make a tortured argument for that being somewhat true. (You could claim, and people do, that the German temperament is excessively given to find comfort in ultra-authoritarian social compacts.) You can make an argument for anything.

But one of the golden rules of reason is to look for the most obvious and simplest explanation for phenomena, before getting into the convoluted stuff. Ideas matter. Humans spend a lot of their period of growth and development internalizing ideas and beliefs that have huge import for their emotional well-being, or lack thereof. In 1945, Germany was a land of weeping and wailing, much of it due to this nation having embraced some real crazy ideas.

Back to the microcosm, the individual human: Our need to attach ourselves to ideas is just fantastic. And there is all kind of competition among purveyors of competing ideas seeking our allegiance. I maintain that this is very stressful . . . and the more caring about ideas an individual is, the more stressful it can get. So, even if one comes from a nice home with decent parents and has led a reasonably safe existence, there is still so much opportunity for the mind to get quite stressed out trying to decide what ideas to appropriate to itself as what it believes in. And some unfortunate minds can latch on to some ideas that are very toxic to hold. And some minds get over-ambitious in their notion of what they can hold themselves responsible for.

My main point is this: A person can be born with an excellent endowment in terms of the physiologic functioning of the brain and still find the pathway to chronic emotional distress broad and easy to wind up following. There is so much that can distress us . . . so much more than what a doggie concerns himself with. I think we've reached that point in our evolution, where what we find ourselves endowed with, in terms of the ideas we internalize, may count for more than the sequence of genes in our chromosomes . . . at least in terms of our mental well-being. And I think it doesn't get enough press.
Thanks for this!
Onward2wards, venusss
  #3  
Old Jan 13, 2015, 02:18 AM
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Why do people have to be invested in looking at a certain aspect of things with some ulterior motive?

Maybe there are lots of people who seek knowledge and understanding for the sake of it and to help their fellow men/women who suffer.

I happen to be very fascinated by it and interested in it. It's what I wanted to do when I grew up. My motives for wanting to go into this field were altruistic.

I said at the outset that this thread was one aspect of things for people who might be interested in reading about it,

If you don't want to read about it then don't. It's a free country and I am not presenting any false information or misrepresentations. Something I have seen a number of times here.

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The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

Major Depressive Disorder
Anxiety Disorder with some paranoid delusions thrown in for fun.
Recovering Alcoholic and Addict
Possibly on low end of bi polar spectrum...trying to decide.

Male, 50

Fetzima 80mg
Lamictal 100mg
Remeron 30mg for sleep
Klonopin .5mg twice a day, cutting this back
  #4  
Old Jan 13, 2015, 02:43 AM
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Originally Posted by zinco14532323 View Post
I happen to be very fascinated by it and interested in it. It's what I wanted to do when I grew up. My motives for wanting to go into this field were altruistic.
That's interesting.

I didn't end up doing what I wanted, either. I think that's why I am depressed.
  #5  
Old Jan 13, 2015, 03:23 AM
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Originally Posted by Rose76 View Post
That's interesting.

I didn't end up doing what I wanted, either. I think that's why I am depressed.
It was actually depression that caused me to drop out of college at 19. I went back for a year or so in my 30's. I have actually had a very fulfilling career as a plumber and in the building trades. To be a master plumber requires a huge amount of knowledge, math skills, problem solving skills, and engineering skills. Designing mechanical systems and architectural drawing in 3D in autocad is quite fulfilling. (I am not talking about fixing your drippy faucet but about all the systems that go into building a big hospital, massive and complex.) In my 20's and 30's I had lots of regrets about it but not for a long long time. I am still very interested in the bio sciences, physics, and all kinds of things. Self taught is as good as school taught to me. I find much satisfaction in learning on my own. And it is never to late. Today I registered for classes to get my building license in MI. I have always worked in CA. There is nothing stopping me from going back and getting an engineering degree........well except depression, that is much more unpredictable than it used to be. If I try and fail, I don't give a crap anymore. At least I tried.
__________________
The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

Major Depressive Disorder
Anxiety Disorder with some paranoid delusions thrown in for fun.
Recovering Alcoholic and Addict
Possibly on low end of bi polar spectrum...trying to decide.

Male, 50

Fetzima 80mg
Lamictal 100mg
Remeron 30mg for sleep
Klonopin .5mg twice a day, cutting this back
  #6  
Old Jan 13, 2015, 04:10 AM
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Wow, I can sure relate, as I dropped out of college due to depression when I was 19. I went back at age 32 and finished, but never did anything with what I studied. I had already established myself in a line of work that I stayed in. I had regrets, but my job gave me reasonable economic security. At times, it was very fulfilling. I figured I could always take more courses and gradually move towards a line of work that might seem more fulfilling and in line with my original interests and goals.

Then, when I went to sign up at a University after the age of 50, I was flabbergasted at the level of computer literacy that going back to school would require. I wasn't even computer literate enough to sign up for the d*mn courses. I had to get special hand-holding just to register. I thought, "Good golly, how am I ever going to be able to even write a paper?" I just walked off the campus in despair, probably magnifying the challenge beyond what I needed to. But that's what depressives tend to do.

After that, my job performance just deteriorated.

Good for you getting registered for those classes. Maybe also look into a class in the bio-sciences. You might consider training to work as a peer counselor. I'm sure it doesn't pay anything remotely like would you can make as a plumber, but it might allow you to use some aptitudes that you were born to develop.
  #7  
Old Jan 13, 2015, 12:15 PM
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If I weren't so tired today I might take a look at the articles. Thank you for posting them.

I believe in the heritability of mental illness - - at least in some cases - - because it occurred on my dad's side of the family: my dad's mother had bipolar disorder. She was in and out of psych wards her entire life, one likely reason being she refused to take medication. She was given nutrition/hydration through an IV because she refused to eat or drink. Her mother committed suicide.

Nature or nuture? Maybe a little of both? In some families there's a clear pattern and that includes mine. It makes me a little concerned about my young nieces. Will they luck out or not . . .
  #8  
Old Jan 13, 2015, 02:02 PM
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Originally Posted by newgal2 View Post
If I weren't so tired today I might take a look at the articles. Thank you for posting them.

I believe in the heritability of mental illness - - at least in some cases - - because it occurred on my dad's side of the family: my dad's mother had bipolar disorder. She was in and out of psych wards her entire life, one likely reason being she refused to take medication. She was given nutrition/hydration through an IV because she refused to eat or drink. Her mother committed suicide.

Nature or nuture? Maybe a little of both? In some families there's a clear pattern and that includes mine. It makes me a little concerned about my young nieces. Will they luck out or not . . .
Makes me very concerned about my daughter for depression and alcoholism. I know she has the alcoholism gene because I have seen first hand how she reacts to alcohol. The phenomenon of craving once the pump is primed is the tell tale sign. The party is over and everyone is asleep and you are walking around looking for half full beer cans and polishing them off because that is all the alcohol left. I have done it myself many times along with many other things. We have talked about it a lot. She is always happy to go to AA meeting with me but she doesn't think she is an alcoholic. I don't think so either but she could easily become one.

She spent much of her teen years in depression and had a half *** attempt.

My great grandfather spent the last 7 years of his life in a spare bedroom at my grandparents house and committed suicide. No treatment really at that time. It was family or state hospital. Then there is the bi polar I and schizophrenia on other branches. Alcoholism runs rampant through all branches.

My daughter is 21 now and since 18/19 has done a total 180. She is very happy, doing very well in college, working....just amazing and I am so happy. She is at risk though, no doubt.

It is always nature and nurture I think. Just to what degree of each one.
__________________
The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

Major Depressive Disorder
Anxiety Disorder with some paranoid delusions thrown in for fun.
Recovering Alcoholic and Addict
Possibly on low end of bi polar spectrum...trying to decide.

Male, 50

Fetzima 80mg
Lamictal 100mg
Remeron 30mg for sleep
Klonopin .5mg twice a day, cutting this back
  #9  
Old Jan 13, 2015, 04:50 PM
Anonymous37807
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I'm glad your daughter is doing better. Hopefully things will remain positive in her life.

My dad drank alcoholically after my mom died. He was "just" a binge drinker before then. I believe my aunt (his sister) had alcoholic tendencies too. Not sure about generations before him.

However, I seem to be the only one among all my relatives right now who is in recovery or has a mental illness. That makes me the black sheep. Not a great position to be in. That's why I really need this site and my friends (all of whom are either in recovery and/or have a mental illness) for support.

Anyway, I digress somewhat from your topic. The fact that there's a history of mental illness in my family, although it makes me feel like somewhat of a victim - - also makes me feel less "responsible" for my bipolar. In other words, there's a reason for it and I'm not just a f**** up.
  #10  
Old Jan 13, 2015, 05:48 PM
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Originally Posted by newgal2 View Post
I'm glad your daughter is doing better. Hopefully things will remain positive in her life.

My dad drank alcoholically after my mom died. He was "just" a binge drinker before then. I believe my aunt (his sister) had alcoholic tendencies too. Not sure about generations before him.

However, I seem to be the only one among all my relatives right now who is in recovery or has a mental illness. That makes me the black sheep. Not a great position to be in. That's why I really need this site and my friends (all of whom are either in recovery and/or have a mental illness) for support.

Anyway, I digress somewhat from your topic. The fact that there's a history of mental illness in my family, although it makes me feel like somewhat of a victim - - also makes me feel less "responsible" for my bipolar. In other words, there's a reason for it and I'm not just a f**** up.
It's fine. I don't care if my threads weeve and bob off topic. I have always been the black sheep of my family too. My brother is also in recovery for addiction/alcoholism but I am the only one with serious mental illness. My sister takes an antidepressant but it has always worked and she never gets it real bad. Two brothers and one sister all professionals and very successful in life. Not that they don't have problems, they do. I have had a good career as a plumber but hitting bottom and getting sober is like starting all over and then the setbacks with depression and now here I sit waiting on an appeal for SSD and it has been over a year since we appealed. I spent 15 out of 18 months in bed suicidal depression. Pdoc, T, family all told me to apply. That idea had never entered my head before. I still have lots of skills and opportunities but how do you get a full time good job with lots of responsibility and good pay and then miss a month of work and expect them to put up with it. Ain't gonna happen. I was so lucky I had an AA buddy for a boss for 11 years who did put up with me missing three to four months a year. I ran his business and he needed me and we worked it out. He was hella cool. I worked from home as much as I could when down and he covered for me in the field. Still didn't get paid for all that time missed.

And yes people in recovery and people with mental illness are by far my best support. My family is great but they can't ever truly get it. I have some cool friends but same with them.
__________________
The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

Major Depressive Disorder
Anxiety Disorder with some paranoid delusions thrown in for fun.
Recovering Alcoholic and Addict
Possibly on low end of bi polar spectrum...trying to decide.

Male, 50

Fetzima 80mg
Lamictal 100mg
Remeron 30mg for sleep
Klonopin .5mg twice a day, cutting this back
  #11  
Old Jan 13, 2015, 09:41 PM
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Rose76 Rose76 is offline
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Originally Posted by newgal2 View Post
The fact that there's a history of mental illness in my family, although it makes me feel like somewhat of a victim - - also makes me feel less "responsible" for my bipolar.
That seems to be so awfully important to so many. It's not that I can't see why. It certainly feels horrible to struggle so hard with depression, or whatever, and be told that you could be different, if you would just take more responsibility and try harder . . . if you would just make better decisions . . . if you would just do this or do that.

Even therapists can totally get on my nerves. I went to them faithfully. Anytime I moved, I located a new therapist in my new community. I would tell them that I have this chronic problem of recurring episodes of depression. So, typically, the T says, "Well, you know you can have a better life than that. If you will just work on your issues, life can hold so much that's wonderful for you." I'ld hear that crap every time I started with a new therapist. Finally, it dawned on me: "What the h*ll do you think I've been doing these past many years, prior to meeting you?"

In one way or another, we are bombarded with judgementalism, and we get desperate to escape that. Because we know that we have been trying very hard, even if no one else can see the truth of that. Years into the problem, we know we have coped with a lot and responsibly accessed what help there is and we still got this monkey on our backs. So, if I'm permanently saddled with this thing, then, Please God, let it not be my fault that I am this way. Let this be in my chromosomes, like sickle cell anemia. Then I'll be worthy of some compassion. Then I won't be to blame. And, if my kids' problems are genetic, then their difficulties won't mean I was a bad parent.

So being an alcoholic is genetic. Being bipolar is genetic. Being gay is genetic. Your kid having ADHD is genetic. Maybe they all are genetic . . . I don't know. But I do know that there is this outlook that, if only we can get acceptance that something is genetic, then we might have a better chance of being accepted as we are. Then we can escape the scorn of our fellow man. Isn't that kind of sad? Are we, any of us, wise enough to sort people into two groups: those who are just f***** up, verses those who are innocent victims of misfortune.

I think just being human is reason enough for anyone to be f***** up, and none of us is responsible for being born human. I'll bet that, even if a person is born with a completely flawless genome, non-predisposed to any ailment whatsoever, he or she can still become an alcoholic or a depressive or a manic/depressive. Would such a person be more deserving of reproach/condemnation than his neighbor with the faulty genes? Such a person would still have reasons for why he got the way he got. There's reasons for everything, I believe.

My main point is that I think we've gotten obsessed with genetic expanations for everything because, as I think newgal's remark illustrates, we've got so much riding on that - namely, our self-respect.
  #12  
Old Jan 14, 2015, 12:07 AM
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I don't see it that way. First of all I decided along time ago it was my job to accept everyone exactly as they are and love them as they are and to forgive. It is not my place to judge anyone. Yes it is true I do not like the judgment of others and people trying to fix me. It drives me crazy.

I think with alcoholism, addiction, schizophrenia, and bi polar I, genetic predisposition will mean orders of magnitude higher chances of them developing it than people without it. I don't think someone without the alcoholism genes can become an alcoholic. Not a true one. That is all besides the point.

I learned an adopted and attitude in AA that has served me well. I took the words blame and fault totally out of the equation when it came to me and the people in my past. I chose to focus entirely on responsibility. It makes no difference at all how I got this way. I am the one responsible to do something about it. I have to own every thought, feeling, and action in my whole life and take responsibility for it. Going down the rabbit hole of causation doesn't serve me to well. Analysis Paralysis.

However I see nothing at all wrong in the bigger picture of taking an objective look at the reasons behind things. No matter what those reasons might be. An engineer has to thoroughly understand the problem before engineering a solution that works. Knowledge and understanding is power. More understanding leads to less judgment and less stigma. Knowledge and understanding leads to better treatments and better outcomes. Humans will always seek to better understand ourselves and the universe around us. No one will ever stop that.

This thread was meant to take an objective look at what evidence exists for one aspect of a very complex issues. Not to shirk responsibility or cast blame on one factor or another. I am totally responsible for my own self acceptance, self love, and non judgement. I am totally responsible for how I respond to the judgement and scorn of others. Don't we all deserve respect and acceptance? Can't we have self respect no matter what the causes are?

Some will argue that there is a huge difference between someone repeatedly sexually abused as a child who then later develops depression and uses self harm to cope and someone who commits pre meditated murder knowing full well what they are doing. Or someone selling drugs and committed armed robbery all the time. Which one is to blame and at fault? Which one deserves the respect and acceptance of others?
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The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

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Possibly on low end of bi polar spectrum...trying to decide.

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Rose76
  #13  
Old Jan 14, 2015, 01:24 AM
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I am not quite sure what you are saying.

Lets say hypothetically someone with a perfect genome develops schizophrenia only through their own actions and having nothing to do with the actions of others. Does that person deserve scorn and judgement? There are reasons but those reasons are entirely their own doing. Do they deserve our scorn and judgment? I think you are saying they don't because as humans we are all doing the best we can with what tools we have. What is wrong with escaping the scorn and judgment of others no matter what reasons we use to do it? What difference does it make if I say it was genetics or if I say my parents were both heroin addicts and abandoned me? And what about Ted Bundy? There are reasons he is the way he is and reasons he did what he did. Does he deserve scorn and judgement? Does he deserve self respect?

Self respect rides on a whole lot of things. I think it rides primarily on self acceptance, self love, and self forgiveness, and yes it rides on how others view us. Why wouldn't we want others to accept us the way we are no matter the reasons of how we got the way we are including genetics? I am sure a black person wants to be accepted exactly as they are and not discriminated against because their genetics gave them black skin. Genetics are rather important in that case because we are born with certain levels of melanin due to genetics and have absolutely no control over it so should not be judged or scorned because of it.
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The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

Major Depressive Disorder
Anxiety Disorder with some paranoid delusions thrown in for fun.
Recovering Alcoholic and Addict
Possibly on low end of bi polar spectrum...trying to decide.

Male, 50

Fetzima 80mg
Lamictal 100mg
Remeron 30mg for sleep
Klonopin .5mg twice a day, cutting this back
Thanks for this!
Rose76
  #14  
Old Jan 14, 2015, 01:36 AM
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Quote:
Originally Posted by zinco14532323 View Post
Can't we have self respect no matter what the causes are?
That's exactly my point that maybe I didn't get across too well.

I don't think we can divide depressed, or alcoholic, people into a) those who are at fault for having the disorder and b) those who are not.

People with genetic-loading for a disorder (and I accept that they exist) are not necessarily morally superior to those who might have a disorder, despite not being genetically predisposed (and I suspect they, too, exist.)

Certainly, as you describe, there is a moral duty incumbent on anyone with any disorder to try their best to manage it as well as they can. Some people take that duty more, or less, seriously than others.

Type II diabetes is often an outcome of the way a person has lived. Many people who wind up with Type II diabetes need never have gotten that disorder, if they had, over the years, made different choices (about diet and activity level.) I'll bet that's true of a lot of disorders, physical and mental.

I'm okay with the possibility that maybe I have genetic factors making me vulnerable to depression . . . or not. I don't need to believe it's genetic, in order to not hate myself.

I have been at support groups where I've heard individuals say, "I suffer from depression due to a chemical imbalance of my brain." That's getting theories mixed up with facts. I don't know, for sure, why I have this condition, and neither does anyone else.

In my case, there is am unbroken chain of mood disorder stretching from me back to my great-grandfather, who died in a state psychiatric hospital. That could mean there is genetic loading . . . or not. It could also mean that, when a person is too moody to be a very good parent, he or she is apt to create a home atmosphere that produces moody children. I'm equally interested in both possibilities. My suspicion is that both those dynamics come into play.

I don't know what the heck is in my chromosomes, but I do remember vividly how awfully stressful it was to have to tip-toe around my moody father. I think that living with a parent who could go from being the most fun guy in the world on Monday to not talking to anyone on Thursday may well have done little to foster a stable emotional affect in me.

It's all interesting, I think. And, as newgal said, "it makes me feel like somewhat of a victim", however the mental problems got passed along the family tree.
  #15  
Old Jan 14, 2015, 02:29 AM
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I guess I have one view in how I approach my case and treatment compared to how society should deal with it.

When I first got into recovery I did feel like a victim from both genetics and my alcoholic "dysfunctional" family. I did lots of analyzing and identifying why I was the way I was and processing and healing all of that. At a point when the anger was gone is when I decided I no victim role, no fault, no blame, and only responsibility, love, and forgiveness. It's not my place to judge my buddy whose toes are falling of because he has never really done what he needs to do with his diabetes.

I don't need to know the reasons to love myself but I would like to know them because it might empower me to do something about it.

As for society I think we should study all the possible reasons as much as we possibly can and all the possible solutions we possibly can and give people the best most current information we can.

What people do with all that is up to them. People have whatever tools and capabilities they have and whatever willingness. I don't fault them.

I think we agree.

On a side note wait until defense lawyers start bringing in brain scans of mass murderers that show huge abnormalities. Not my fault. Probably already happening. Responsibility and consequences are still key words.

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__________________
The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

Major Depressive Disorder
Anxiety Disorder with some paranoid delusions thrown in for fun.
Recovering Alcoholic and Addict
Possibly on low end of bi polar spectrum...trying to decide.

Male, 50

Fetzima 80mg
Lamictal 100mg
Remeron 30mg for sleep
Klonopin .5mg twice a day, cutting this back
  #16  
Old Jan 14, 2015, 02:37 AM
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And of course I focus more on biology because I wanted to be a bio psycho pharmo neuro dude when I grew up. It totally fascinates me. It's my little role. Venus can play her role. Rose can play her role. All valid.

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__________________
The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

Major Depressive Disorder
Anxiety Disorder with some paranoid delusions thrown in for fun.
Recovering Alcoholic and Addict
Possibly on low end of bi polar spectrum...trying to decide.

Male, 50

Fetzima 80mg
Lamictal 100mg
Remeron 30mg for sleep
Klonopin .5mg twice a day, cutting this back
Thanks for this!
Rose76
  #17  
Old Jan 14, 2015, 06:14 AM
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Quote:
Originally Posted by zinco14532323 View Post
And what about Ted Bundy? There are reasons he is the way he is and reasons he did what he did. Does he deserve scorn and judgement? Does he deserve self respect?
Yes, Ted Bundy deserved scorn and judgement.

So do I, when I act like an a**hole, which on occasion I do. Sometimes, I need the scorn of those around me to alert me to the fact that I am acting like a jerk. There is nothing wrong with appropriately directed scorn. It can be a healthy human response and it serves a necessary function. That's why humans evolved the capacity for scorn.

Let's look at self-respect. I checked a few dictionaries and came up with the following. Self-respect means a sense of one's own dignity that motivates a person to have a self-imposed standard of how he will behave and how he will tolerate others behaving toward him. Having self-respect means a person won't do certain things because he considers them to be unworthy of who he is, even when he could get away with doing them and profit by doing them. It means he won't accept certain treatment, even if he must die to defend himself from it, because he feels it is incompatible with his dignity.

Bundy didn't seem to think that any behavior was unworthy of him. So I don't think he was ever able to develop any solid self-respect. Having self-respect is like having a strong back. It's the result of self-directed effort. No one can give it to you.

T. Bundy spent his earliest years around a grandfather who was a monster. So, yeah, there's reasons for him being as he was. Could he have chosen to turn out other than as he did? I have no idea.

Were Bundy alive today and serving out a prison sentence, would he deserve any respect. Our correctional system purports to accord all inmates with respect to the extent that that is possible in the context of how they are behaving today. Sam Berkowitz seems to be on quite good terms with the folks around him. He has been given constructive duties to perform that he carries out conscientiously. You can Google up a website that his Church friends have organized for him and view videos of interviews he's given. He comports himself with good humor and an apparent measure of maturity. Is that just a fiend making the best of his limited options? Possibly not. I do think there are some disturbed minds that require the constraint of institutionalization to find their moral bearings.

Last edited by Rose76; Jan 14, 2015 at 06:27 AM.
  #18  
Old Jan 14, 2015, 06:40 AM
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Originally Posted by zinco14532323 View Post
As for society I think we should study all the possible reasons as much as we possibly can and all the possible solutions we possibly can and give people the best most current information we can.
I wholeheartedly concur.
  #19  
Old Jan 14, 2015, 08:09 AM
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The more we talk Rose the more we have in common. Great Grandfathers, moody fathers, tip toes, elephants in the room, college, career, depression, etc...gotta be more.

Actually I haven't noticed biology and genetics talked about that much in these forums. Once in awhile someone will throw out the diabetes/ insulin analogy (like prozac is insulin for the brain) or the chemical imbalance theory. We both know neither one is valid.

There is one of the Kennedy's on TV all the time saying "mental illness is a matter of chemistry not character," in an effort to reduce stigma.

The media message that depression is easily treated so seek treatment which means meds. Bull crap it is easily treated!

I only go to depression, addiction, ACOA, and psyche meds but I don't see biology brought up that much.

I would guess that only 5 or 10% of my 4500 posts mention meds or biology. And those would all be in the sometimes long debates we have or in the psych med section. I might spend a long time reading a study and pointing out that Robert Whitaker totally misrepresented a study in a video lecture someone posted. He claimed the study proved something and the authors of the study said no such thing and no rational person could conclude that the study showed what he said. Or a doctor who wrote an article that is often posted who also totally misrepresents what a study actually says. The authors of the study actually contradict what is claimed in the article. The lead author in interviews says the study doesn't say what so much of media and doctors are claiming. That's one of the reasons I say people should be given the most accurate, most current information possible even if it is incomplete. There are lots of things we just don't know.

The other 90% of my posts are just supportive or I share parts of my story and don't mention biology or meds. I see the push in society to blame biology to reduce stigma but I really don't see it that much here or in the people I know who have MI.
__________________
The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

Major Depressive Disorder
Anxiety Disorder with some paranoid delusions thrown in for fun.
Recovering Alcoholic and Addict
Possibly on low end of bi polar spectrum...trying to decide.

Male, 50

Fetzima 80mg
Lamictal 100mg
Remeron 30mg for sleep
Klonopin .5mg twice a day, cutting this back
Thanks for this!
Rose76
  #20  
Old Jan 14, 2015, 09:49 AM
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I think I've been misunderstood. When I wrote about being responsible for my bipolar I didn't mean I don't have to do anything about it. I mean it is not entirely due to my poor coping skills or improper perspective that I experience mood swings. My family history suggests it's - - at least in part - - genetic for me.

And I never said I'm morally superior to someone who didn't inherit his or her mental illness. I do not judge anyone with a mental illness, whether they inherited it or not. I am very accepting of ALL people, no matter what mental illness or trait or life circumstances have befallen them.

I didn't come on this site to argue, so I'll stop with that. Thank God it's a free country and we're all entitled to our opinions. Hopefully free from character judgment.
Thanks for this!
Rose76
  #21  
Old Jan 14, 2015, 06:40 PM
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zinco, thanks for the heads up on Whitaker. I just discovered him, via a PC post, and was rather impressed with the video that I half-listened to. He did seem a bit less literate on medical terminology than what I would have expected of a journalist writing on that field. I'll attend more closely to how he interprets studies and check sources.

Yes, a lot of commonality of experience in our histories.
  #22  
Old Jan 14, 2015, 07:02 PM
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Robert Whitaker makes many valid points. This was one lecture. I have watched him and agree and disagree. If you want side of the argument read madinamerica.com. There is much I don't agree with in Peter Breggins writings. I decided not to use madinamerica and toxicpsychiatry.com as a source. I like to go straight to the source and look at the most recent studies published in journals like nature or New England journal of medicine be cause you can read what the people who did the study felt they could conclude and talk about the limitations and so on. Very strict standards for getting published in a journal like nature. Always peer reviewed. Harvard, Stanford, John Hopkins, like that.

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__________________
The "paradox" is only a conflict between reality and your feeling of what reality "ought to be." -- Richard Feynman

Major Depressive Disorder
Anxiety Disorder with some paranoid delusions thrown in for fun.
Recovering Alcoholic and Addict
Possibly on low end of bi polar spectrum...trying to decide.

Male, 50

Fetzima 80mg
Lamictal 100mg
Remeron 30mg for sleep
Klonopin .5mg twice a day, cutting this back
Thanks for this!
Rose76
  #23  
Old Jan 14, 2015, 09:19 PM
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Zinco, thank you for posting the articles. I would like to read some of them. I believe depression and mental illness likely has a genetic, biologic, and perhaps environmental causes. I have suffered depression off and on during my adult life. I, too suffered a depressive episode at age 19 or 20 that caused me to drop out of college. Looking back, I wish I had stayed in college and just changed my major.

Your personal story is interesting and is a story of triumph. You have had your difficulties and challenges, but you don't give up. Also, you are very helpful to the rest of us here.

I can remember a time when I did not believe people should take psychiatric medicines. Now I am of the opinion that if medicine helps a person function and have a decent productive life then by all means, lets have the medicine.

You impress me as a very intelligent, dynamic person. I wish you well if you intend to go back to school.
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