Risperdal and side effects

How long do side effects last? My sinuses are killing me, hard to breathe - have asthma as it is, and a bit of nosebleeds. Argh.

when did you take the risperdal? what size dose?

I take it twice a day - 0.5mg each time, along with celexa and seroquel

i can'at find any listing for the side effects you detailed. and your dosage is small. i think you should call your doctor manana and talk to him/her about this. try some heat, moist cloths, on your sinus and sometimes it is helpful to fill a basin with hot water and put a towel over your head and breathe the steam in.....be careful though..don't get it too hot.......i'm hitting the hay....long day....let me know tomorrow how you are doing. pat

Thanks ((((((((((pat))))))))))) for the suggestions. Will do that. Uh, one thing - i can guess, but just want to be sure... what's 'manana'?

SS8282 - Although, rhinitis (stuffy nose, hay fever-like symptom) is a more common side effect of Risperdal (risperidone), the drug also has a significant antihistaminic effect, as a secondary effect. Some people are more sensitive to this effect than others; quite probably because they have a greater number of histamine-H1 receptors, &/or their histamine-H1 receptors are more sensitive to the effects of Risperdal.

This is usually one of those "start-up" side effects that do decrease in severity over the course of a couple or three weeks, as the body adjusts to the effects of the drug.

I hope that this is of some help. - Cam

i'm sorry.......manana means tomorrow in Spanish.....are you feeling better?

(((((((((((((((((((((((((Hello!))))))))))))))))))))))))))))

I am on Risperdal that I take w/ my bedtime meds. I have COPD (which includes asthma & chronic bronchitis) I have to sleep in an almost "sitting up" position.

Risperdal causes weight gain, agitation, headache & most importantly in contraindicated in ppl w/ breathing problems d/t possibility of aspiration pneumonia..........

I suggest you talk to your doc immediatedly!!!!! He may want to adjust the dose or take you off it completely (d/t your nasty side effects. )

(((((((
DAYZEE))))))))))))))))))))

Thanks for the spanish lesson. Still pretty blah though.

With side effectslike these, they should make it illegal, especially if weight gain is one of the effects. j/k. I do realize that it helps some people.

Can you take a different med?

Thanks for the info ((((((((dayzeeeeeee9))))))))))))))))))))))

Your info helped. You gave me some hope that things ought to get better in a few weeks. Wondering though - would taking my other meds make the side effects worse than it would've been had I taken respirdal alone?

SS8282 - When combining medications with similar mechanisms of action and similar side effect profiles, those side effects can be additive. Risperdal (risperidone) and Seroquel (quetiapine) do have similar mechanisms of action, but their secondary effects are slightly different. That is, these two molecules primarily bind to (and block) the same receptor sites (ie. dopamine-D2 & serotonin-5-HT2), but Seroquel and Risperdal do not just bind to these receptors exclusively.

Risperdal secondarily binds to (and more weakly to) alpha-adrenergic-1, alpha-adrenergic-2, dopamine-D1, histamine-H1 receptors, serotonin-5-HT1A, serotonin-5-HT1C, serotonin-5-HT1D, and sigma receptors.

Seroquel secondarily binds to alpha-adrenergic-1, alpha-adrenergic-2, dopamine-D1 and serotonin-5-HT1A receptors like Risperdal; although they do differ in the binding affinities (ie. the two drugs differ in the strength with which the bind to these receptors). Unlike Risperdal, Seroquel does not have any appreciable affinity for serotonin-5-HT1C, serotonin-5-HT1D, or sigma receptors.

It is the difference in the binding profiles, both in strength of binding to the various receptors, as well as binding to totally different receptors, that result in the differences in side effects between the two drugs.

When taken simulanteously, there are overlaps in both primary and secondary receptor binding profiles. Where the two drugs' binding profiles overlap the side effects that are a result of this binding are often additive. Both Risperdal and Seroquel significantly block histamine-H1 receptors, whose main effect is somnolence (ie. drowsiness), as well as possibly contributing to the drying effect that you are experiencing. These side effects are additive.

**** BTW - I want to confess that my last post to you contained an error. I said that the drying effect was due to blocking cholinergic receptors (which is what happens when this receptor is blocked). I looked up the receptor-binding profile of Risperdal today, and discovered that Risperdal has no affinity to cholinergic receptors. I have fix the other post by replacing anticholinergic receptors with antihistaminic receptors; both of these receptors cause similar side effects and the mistake was a mental lapse). Cholinergic receptor blockade has a much stronger drying effect than histamine-H1 receptor blockade, thus I automatically wrote anticholinergic, rather than antihistaminic without looking up a reference (as I should have). Sorry for any inconvenience. ****

So, in answer to your question, it is possible that taking Seroquel with Risperdal will probably increase drowsiness and a feeling of "sluggishness", and may contribute some to the drying effects that you are experiencing; both most likely mediated to the blocking of the histamine-H1 receptor. I would also be willing to hazard a guess that your body may be extra sensitive to the blockade of this receptor.

I hope that this corrects and clears up some of my unintended muddying of this topic. - Cam

Just as an aside, Cam, were you familiar with this smokin' cool receptor affinity database?

http://kidb.cwru.edu/pdsp.php

Your drug being considered would be the test ligand. What's really cool is you can look at a specific receptor isoform, across all drugs....stuff like.

Lar

Thanks Lar! - I have always had fun trying to match drug effects to receptor binding affinities. This will make it much easier. The papers that I have all seem to contain the occasional conflicting value. I was preparing a lecture once and that just drove me crazy.

The internet is really starting to become a useful tool. There are some really intelligent people out there that are willing to share the life's work without slapping a patent on it and charging throught he nose for the priviledge using their information. It is the availability of information of this quality that almost restores my faith in humanity (that is, if I believed in the concept of "faith"). Thanks again - Cam

You did clear things up (though my nose is still stuffy) - made a bit more sense. And there was no inconvenience at all. It is human to make mistakes, but it is the 'better' person to admit and amend. Does that make sense?

Hmmm. I wonder if I can take something like claritin to clear my nose. It's about time I start taking them anyway for allergies,etc.

Oh, and I've got to go away for 2 weeks in May with family, and because my family doesn't know about these meds (psych ones) I don't want to bring them, since there will hardly be time alone to take them without anyone seething them. I also don't want to explain if I get picked to be searched at the airport. So,my question is would it be a problem if I stop these meds for 2 weeks? I know a bit about withdrawal, but since I'll be taking risperdal for just over a month by then, that isn't enough time for withdrawal symptoms - or am I wrong?

do you ever use a saline solution spray for your stuffiness? i like it alot.it's cheap!!

SS8282 - BTW - The stuffy nose is due to alpha-1-adreneric receptor blockade which is an effect of both Risperdal and Seroquel. The effects of the two are more than likely additive, but your body should adjust.

Take the Claritin (loratidine) if you are going to take it for allergies, anyway. Nasal sprays don't usually clear the rear sinus cavities, so generally aren't as effective as oral antihistamines.

Just a further note. - I'm off to bed, as I work out of town for the next few days. - Cam

Yes I have, and I also take flonase - but it's not working all that well.

Thanks ((((Cam))) Good luck with work, and be safe in travelling.

Had an asthma attack last night that was different than my usual attacks. I was so scared.

Oh SS, I am so sorry. Asthma stinks. But listen dear, it's just breathing, don't make a big deal of it.

i'm sorry..asthma sucks...sorry the spray won'twork....didn't know that it wouldn'thelp rear sinuses..

((((((((((((((((((((((ww)))))))))))))))))))))))) i'll try to remember that. Thanks.

Is ok. You reached out to me and tried to help. I appreciated that. Thank you. Hugs.

you're welcome. are you better?