[BlessedRhiannon]

I've been taking Seroquel since August for bipolar2, and have done very well on it. I had a depressive episode around Thanksgiving, and my p-doc added Wellbutrin. Now, I'm out of the depression and the Wellbutrin has thrown me in to a hypomanic state. My p-doc wants me to discontinue the Wellbutrin and add in Depakote. He's starting me at 250 mg 2x per day.

What can y'all tell me about Depakote and/or Depakote in combination with Seroquel?

[Blue_Bird]

I am on Depakote, it has helped me a lot with the hypomania/agitation I was experiencing. My doctor also added Seroquel to my med regimen the other day, so far it seems fine. I'm pretty calm, no bad side effects.

[Moogieotter]

Depakote is a solid MS.

[BlessedRhiannon]

What, if any, side effects have y'all noticed?

[waggiedog]

Hi there. Yeah, I'm on 750mg Depakote, along with Seroquel 200. When I started on these meds I slowly gained weight which shocked and annoyed me. However, the weight has gone down and with these two meds my obsessive intrusive thoughts are much less. XX

[4aminsomniac]

Gave up on it when trying to go above 250mg. Worsening side effects, vision issues/light sensitivity (have always been that way with other stuff), stuffy head/allergic type symptoms. Brain fog, out of it feeling, fatigue...basically, go down the list of well reported side effects, I seem to get them on all of the AEDs, and most meds for that matter. Except Benzos.

Everybody is different, by brother is on 750mg depakote, swears by it...so even a blood relative could have a completely different opinion and outcome to something.

[BlessedRhiannon]

I wanted to follow up on this thread with my experience -

I tried Depakote for a month at 1000 mg (split, 500 mg AM and PM). It was horrible!!!

I was nauseated the entire time I was on it and even though I could barely eat anything, I gained a ton of weight that I am now trying to lose. I felt bloated, my energy was completely sapped, and I felt mentally foggy all the time. I felt like I had the flu for a month. Within less than a week of coming off of Depakote my energy has returned, the nausea went away, I feel mentally sharp again.

Not a drug I'd be willing to try again. I know it works great for some people, but for me, it was a month of torture.

[BlackSheep79]

Originally Posted by BlessedRhiannon

I wanted to follow up on this thread with my experience -

I tried Depakote for a month at 1000 mg (split, 500 mg AM and PM). It was horrible!!!

I was nauseated the entire time I was on it and even though I could barely eat anything, I gained a ton of weight that I am now trying to lose. I felt bloated, my energy was completely sapped, and I felt mentally foggy all the time. I felt like I had the flu for a month. Within less than a week of coming off of Depakote my energy has returned, the nausea went away, I feel mentally sharp again.

Not a drug I'd be willing to try again. I know it works great for some people, but for me, it was a month of torture.

I was on Depakote years ago and gained 40 lbs in a short period of time. Right now I'm trying to get off of Seroquel even though it's been a savior, I want to see if I don't need it. I'm laying on the couch right now with flu symptoms just like the last time I came off of it. I'm doing this with pdoc instructions like last time it's just the way my body reacts. Anyways, I've been on Lamictal for probably seven years I think, using it as a mood stabilizer. Have you tried it?