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mikrw33
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Member Since Jan 2013
Location: Madison, Alabama, USA
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Default Mar 26, 2024 at 09:30 AM
  #1
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Originally Posted by mar dhea View Post
Antidep I've been taking for years [tried both generic & namebrand] don't seem to be doing much anymore. Wellbutrin is the name. Bupropion. Extended release. 300mg once a day.

Would like to hear from any long-term users of this med who switched to something they found to work better.
You have just a little more room to go up with bupropion. You can go up to 450 mg/day safely. Beyond that increases the risk of seizures without any additional benefit.

Also, you could ask your pdoc about adding sertraline (Zoloft). It's a great adjunct to bupropion because it's a CYP2B6 inhibitor, which inhibits bupropion's metabolism to hydroxybupropion, which is primarily a norepinephrine reuptake inhibitor. Adding sertraline balances out the dopamine reuptake inhibition relevant to its norepinephrine reuptake inhibition, plus adding serotonin reuptake inhibition to the mix. Also, sertraline is a mild dopamine reuptake inhibitor to boot.

__________________
Diagnoses: Tourette's Disorder, OCD, ADHD-PI, Bipolar I Disorder, Borderline Personality Disorder, Anxiety Disorder Unspecified

Medications:
Dyanavel XR 15 mg 30 mg/day
Lamictal 300 mg/day
Cymbalta 90 mg/day
Lunesta 3 mg/night
Dayvigo 10 mg/night
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Thanks for this!
mar dhea
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