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Old Feb 06, 2017, 08:34 PM
Nene873 Nene873 is offline
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My psychiatrist said that since Wellbutrin XL helps with my depression but makes me edgy and irritable, he's going to switch it to Wellbutrin SR twice a day and I should experience less irritability with the SR type. Does anyone know why the XL would cause those side effects and the SR type would be less likely to do so? Anyone know what the big difference is?

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Old Feb 06, 2017, 08:42 PM
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Moose72 Moose72 is online now
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I'm on XL. I don't feel edgy or irritable. I have in the past before Wellbutrin. I really like wellbutrin in general. I can feel sad when appropriate but not depressed. Of course I haven't had depression in 2 years or so now. I get more mania or hypo or anxiety side of depression I guess.
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Old Feb 07, 2017, 10:33 AM
Nene873 Nene873 is offline
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No one else? Anyone?
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Old Feb 07, 2017, 10:37 AM
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I was originally on Wellbutrin XL and it did make me irritable and agitated, plus it gave me insomnia. Switching to SR really made a difference. As far as exactly why, I'm not the best one to answer about the pharmacokinetics/pharmacodynamics between each. Everyone is different in how they react to any particular drug.
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Old Feb 07, 2017, 11:11 AM
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The IR made me a little jittery. I'm on 300mg of XR and is much better.
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  #6  
Old Feb 07, 2017, 05:49 PM
Nene873 Nene873 is offline
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So, I was taking 450 mg of Wellbutrin XL and have been for a little while and bumping along with the irritability and edgy-ness.. and my psychiatrist told me to lower it to 300 mg on Thursday before we tried the SR version. I've been on the 300 mg since Friday and this morning I had to go back up to the 450 mg because I'm just too tired on the lowered dose; I mean I am wiped out and completely unmotivated to do anything. I have sat on the couch in my pajamas for 3 days. Plus, my mood is sliding back into depression.

I'm just going to have to deal with being irritable or replace the Wellbutrin XL with something else. I contacted my psychiatrist this morning to let him know what the situation was but I haven't heard back from him yet. I am so impatient and waiting to hear from him is hard. I hate not having any control in what meds I can get when I need them. I do have an idea of what AD I'd like to try.
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