? Solution ?

So what does a person do, when, because of depression, they can't keep a job for very long, they continually disappoint others and ruin most relationships, they no longer have any real friends, and now are a burden on their family at 40 years old? I think there comes a point where you (me) lose hope.
I've had depression for the past 19 years. Sometimes I feel hopeful, as if I can find a purpose and some enjoyment in life. "This year will be a great one!" Then, soon I have cancelled on something/someone, I have quit a job, I have slept through an appointment, I have disappointed my mom and sisters again....
At some point, I am realizing things are not going to change.

Wow yr family isn't being supportive at all huh? You really need them and they don't seem to realize that. Maybe you should look into getting ssd cause you have trouble keeping jobs? That's what I had to do. I kept getting fired from my jobs and I couldn't keep one to save my life. Now I collect ssd and work a pt job. It's very supportive and flexible which really helps me. I'm also in my 40s...I'm 44. I really understand the feeling of losing hope. Do you have regular therapy every week? It helps me not feel so alone. I'm so sorry you have no friends...you don't have anyone to be there for you? Why do you feel that you disappoint yr mom and sisters? You really need them for support esp if you don't have any friends you can talk to. Please know that we're here for you! Depression is hard but it's harder if yr suffering alone. Feel free to pm me anytime ok? I'll be here for you to listen and support you.
:-)

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Very good questions. I'm searching for answers for those myself. I do hope things get better for you, tho.

Have you had any therapy or worked with anyone else to try and break the negative patterns you have set up over the 19+ years? It is hard to change one's life, even without being depressed.