Please help me understand this

I'm actually not sure how long it took to "relapse", it was a long time ago. Maybe a month?

Although it was not a relapse. I had no history of depression before the med. I was taking it purely for anxiety.

Strange, maybe you should give herbal medicines a shot such as 5ht which increase serotonin naturally.

THAT IS A LOAD OF CRAP, I have taken ssri,s for 35 years and now take the smallest dose I have ever taken , in you summary I should have been dead 33 years ago. That guy was a GP I no more than most GPs obout meds . There medical docs not shrink docs

I have tried 5htp. In this case, it made no difference. I was without am SSRI for three years and my depression did not stop. It's like I'm brain damaged forever. I did however find another SSRI that doesn't make me depressed and lifted me almost to the level where I was before the Zoloft.

I'm not sure the depletion happens just like the video says. It is possible. But it is also possible it occurs in another way. Nevertheless, tardive dysphoria is a real thing. The mystery is just why some get it and some not. Some people can take Zoloft for five years, stop and they are still well.

Serotonin depletion and brain damage doesn't equal death. Just because they are not psychologists/psychiatrists doesn't mean they aren't professionals You might have direct first hand experience which is limited to your own personal bias, but I doubt you know more than them about how the body and brain works.

A GP has virtually no answers for you on mental health its not there chosen job. They have to look in a book for meds, that's why your sent to the mental hospital, if my serotonin was completely depleated in 3 years like you said of course I would be dead. 35 YEARS ON SSRI.S megga dose a lot of times, now I take just 10 mg of Lexapro so you theory is loony tunes. you just need a new med

I never said your serotonin becomes completely depleted it becomes partially depleted. It's not just MD's saying this it's psychiatrists and psychologists alike. I'm not here to convince you anyways.

Sorry im out you make no LOGIC, You just take a med or you don't your choise, I needed meds or I would have died simple no brainer, I don't constantly worry about them after all its been 35 years since I took them and im still crazy but cool with it. I don't for one minute believe serotonin depleats, you have a certain amount and ssri,s make sure you get the the right amount . It don't just leak out your ears and disappear SSRI,S GIVE IT A HELPING HAND TO DO ITS JOB.

Mabye this will help clear it up. According to this article, the deficency or depletion only occurs in people with a rare mutation in the tph2.
Chronic SSRI treatment exacerbates sero - PubMed Mobile

That makes sense. I wondered why some people can take SSRIs for years and not become harmed in any way.

Yea, it does. Ive taken Ssris off and on for 18 years and Im fine when I go off of them. I usually go back aftr a few years or if my stress & anxiety levels get too high for meditation. But Ive also seen people who use them for depression ir anxiety & are never the same again. But for the most part, people are fine.

Sure I can believe that , its like a simple ALLERGY I am allergic to penicillin .1 in a million rare mutation like you say. Me an many others can only go on many many years of using SSRIS TO KEEP US ALIVE, to be told that short term use will nuke you by someone who dare not try themself because some nut ball on the net said not makes my arse laugh , sorry it just wound me up.

Eh. I was on Zoloft for 3 years. Doubt I was allergic. Had an allergic reaction to Lamictal. Almost killed me!

I was using allergy has a point. Serotonin depletion is a 1 in a billion thing , Allergies are similar but not any where near has rare . there are people telling the poster they are cool after 40 years on SSRI,s and he still looks at quack md internet rubbish , convincing himself his brain is going to die in 2 years.

I'm not sure I believe in this type of serotonin depletion either, but I'm waiting for more info. If it was totally true, I wonder why another SSRI is helping me with the damage caused by Zoloft?

In the early rat studies (in the 90s) some of the SSRIs killed off the norepinephrine receptors in rats. If it happens in humans it will affect you. The different transmitter substances seem to affect each other.

What I hated the most about SSRI besides the withdrawal period was this "side effect" they called "akathisia" or even worse was the "psychomotor agitation" that I got from taking stimulants when they said I had ADHD, between Wellbutrin and Concerta I also developed Obsessive Compulsive Disorder which took years of psychotherapy to overcome. I still have restless leg syndrome but I can't really blame the drugs cause that runs in my family.

Akathisia is basically this feeling of inner restlessness that makes it so you can't sit still, you dance around when you are standing and you can't stop moving, you can't sleep. While I was on Paxil I had 4 suicide attempts due to this horrible feeling coupled with the mental stress I was already subjected to living in an abusive home. It made me more angry, more depressed and made my anxiety so high the feeling was unbearable. I wanted to die, I am still to this day reluctant to take anything prescribed by a psychiatrist because of the poor management of my medication 11 years ago.

I self medicate with herbal MAOI and find they work better for my attention, motivation and depression than anything I ever tried before.