[Sometimes psychotic]

Discovery of novel drug target may lead to better treatment for schizophrenia

So pretty much every antipsychotic is a D2 inhibitor. In some of the GWAS studies there is a protein called DISC-1 that appears to be mutated in some patients. Apparently DISC-1 binds to and interacts with the D2 receptor and a chemical inhibitor of that interaction was found to have anti-psychotic properties. This is interesting to me because it may be a more direct target for some people but may help everyone and have a different side effect profile that may be gentler than straight out inhibiting dopamine.

[Atypical_Disaster]

Sometimes psychotic, thank you for sharing!





If this research leads to them developing AP's that don't cause weight gain I'm all for it!

Lack of EPS would be lovely too, I am so sensitive to that it's ridiculous.

[Sometimes psychotic]

And thank you for thanking me for sharing

Thanks! I will have a look at this later.

Originally Posted by Sometimes psychotic

And thank you for thanking me for sharing

LOL

Originally Posted by Atypical_Disaster

If this research leads to them developing AP's that don't cause weight gain I'm all for it!

Lack of EPS would be lovely too, I am so sensitive to that it's ridiculous.

Agreed. More options can only be a good thing for people.

*Willow*

[Sometimes psychotic]

I was trying to find the paper and ran across this picture. This is the typical scientist pose---put on the white coat grab a pipettor of some sort and smile....

This is Dr. Liu who authored the study. I can tell she's legit because she has biorad ladder standard stickers on her bench

[Axiom]

That's really cool, thanks for sharing and for explaining it so well. Hope this passes the trials and becomes a new treatment option.

Winning! I don't have any side effects that I can tell with my Geodon but I hope this works for others.