[hamster-bamster]

I had awful akathisia on high doses of Seroquel, but not on low doses. It also did not work for me as an anti-manic agent, but it sure helped me sleep soundly. I read here on this board that people take as little as 50 mg for sleep and are happy with the results. I wonder if it loses effectiveness over time. I have seen Trazodone and Benadryl and Temazepame lose effectiveness, but was thinking that perhaps anti-psychotics do not lose effectiveness.

Will appreciate opinions from long term users.

[Tsuki632]

I'm curious too about the low dose and sleep over time. I've developed tolerance to many meds.

[medkev13]

That's something to ask your Dr about. Please let us know what you find out though

[hamster-bamster]

Will do. I have a friend who is a p-doc and he says that APs, unlike tranquilizers, do not lose effectiveness. That would be good if it is true!

[medkev13]

APs and ADs tend to require you increase dosage for a while but they do eventually plateau and remain steady.

[Rachel.i]

Originally Posted by hamster-bamster

I had awful akathisia on high doses of Seroquel, but not on low doses. It also did not work for me as an anti-manic agent, but it sure helped me sleep soundly. I read here on this board that people take as little as 50 mg for sleep and are happy with the results. I wonder if it loses effectiveness over time. I have seen Trazodone and Benadryl and Temazepame lose effectiveness, but was thinking that perhaps anti-psychotics do not lose effectiveness.

Will appreciate opinions from long term users.

I take 75 mg. for sleep and it hasn't lost effectiveness for me. I was started out at 300 mg. about 4 1/2 years ago, which was much too high for me, and I've been on 75 now for about 1 1/2 years and it works fine, usually (unless I'm too stressed about something, then not much works).