On very low dose of Seroquel. How does it make you feel?

I'm on a very low daily dosage (100mg) of Seroquel. Prescribed to combat the "psychotic features" that are accompanying my severe Major Depressive Disorder.

I've only taken one tablet and did not "fall asleep in minutes" as my psychopharmacologist had warned. Neither did my delusional voices 'go away.' Maybe for an hour they were less severe. The only things that I've felt, in fact, are heart flutters (probably because of my Long QT Syndrome) and headaches.

If anyone is or has been on this type of low dosage can you describe what it made you 'feel like'? For example 10mg of Xanax daily (one 2mg plank 5 times daily made me feel less anxious but also made me very very quiet and, well, [I]sleepy[I].

I just don't trust the two primary members of my treatment team any longer. I'd like other subjective opinions first before going much further.

Thanks to anyone willing to share an experience.

You are on the sustained released version which doesn't have the same immediate effect of the regular version of seroquel, so no, you probably won't fall asleep quickly.

I used to take 50mg of the immediate release seroquel. It didn't make me sleepy within minutes but it definitely helped me sleep. It would make me quite twitchy just before I fell asleep but that was the only side effect really. I once got given the extended release by mistake and it did not help me to sleep..

100 mg just makes sleepy. It's all consumed by histamine receptors, It's not stabilizing mood swings nor effecting to psychotic features. 200-400mg bonds also to serotonine receptors and effects mostly mood stabilizing. over 400 bonds also to dopamine receptors, which begins to have effect on more severe mental issues.

This is what i've been told and i have personal experience that this is pretty much how it works for me. I use occasionally 50-100 for insomnia. It has absolutely no other effects but knock me out. 200 mg prolong brings down hypomania and paranoid thoughts in couple of days. Zero effect to depression.

if it's prescribed for psychotic features i would recommend to ask if your doc might want to check your dosage.

About 9 years ago I was taking Seroquel for 5 years and it really helped me for depression, voices, psychotic events. It helped with my sleep also. But I had to go off it because I got a new job driving a public bus and Seroquel was something you can not take while driving a bus. I am still driving a bus but I wish I could go back on it. It really helped me to feel better.

I'm on 300 mg and it definitely makes me feel sleepy. I take 200 at night, 50 mg in the am and 50 mg at noon. It really helps with my anxiety.

splitimage

I have been taking 100 mg for years. I have had nights where I have missed a dose and no sleep was had. I suppose we can develop a tolerance to any meds if we take them long enough.

Seroquel affects people in different ways. Our bodies are so different. Some people have a very high tolerance for it and others so low that they are unable to take it.

Thanks, everyone... I slept last night but I don't think that the Seroquel had anything to do with it.

One reason that I have so little trust in my psychopharmacologist is that she's so – conservative when treating severe disorders. She knows that one of my greatest fears is to be hospitalized again but that seems like what she would prefer rather than a more aggressive drug treatment.

This is one of my more lucid moments since yesterday.

After taking one tablet, I can say that Seroquel, in a 100mg dosage, didn't make me feel a thing. I still awoke early this morning because of the singsong auditory hallucinations and am having them from three different sources, all three different songs, music and talk radio.

And half of me is still over the edge and will come back again.

Thank you all so much,

I still think your dose is toolow to effect how it was supposed to.

I'm frustrated with Seroquel. At higher doses it didn't really do anything positive for me. When I began taking Geodon I stopped taking Seroquel - and experienced horrible insomnia and nausea. So it seemed that the Seroquel wasn't really doing anything for me, but when I stopped taking it I had bad withdrawal effects.

So, I decided the best thing to do is take 50mg at bedtime to help me sleep (I take immediate release Seroquel). For the first two weeks, I slept really well and felt very good. Unfortunately, I've noticed that this week my sleep isn't nearly as good...takes a long time to fall asleep & I awaken really early.

As for any other positive effects (lessening delusional thinking), at a low dose Seroquel doesn't do anything helpful. But then...it didn't really do anything helpful at the higher dose, either. Maybe a very slight anxiety reduction - sometimes.

That's why I started taking Geodon - which is helpful. At least, so far.

Just wondering if your treatment team is going to increase the dose of Seroquel? A larger dose may be more effective for you.

I am a senior now and my body has drastically changed in ow I react to med dosages. I m only on 6.25 mg of seroquel, one fourth of a 25 mg pill, and so far it is working beautifully as a mood stabilizer. But even at that low dose I get enough side effects that if the ativan didn't remove them I would not be able to take it.

Old post I know, but I figured I'd respond, since I have been taking a very low dose (25mg/day) of Seroquel for about 4 weeks now and it seems to be edging me into hypomania. Over the past 5-7 days I've noticed more energy, more motivation, and I'm more distracted. My fairly severe depression (what my psych prescribed the Seroquel to assist with) is gone and I feel good. The only telltale sign of mania/hypomania that is not present is reduced hours of sleep. In past episodes I would only need 3-4 hours of sleep per night (as opposed to all other times when I need about 7-8 hours per night). That is not happening as of yet. Seroquel does kind of knock me out, so maybe it's canceling out.

Interesting. I'm glad you posted this. I'm currently taking 50mg. Seroquel and, although it does help me sleep, I feel very anxious and, at at times, hypomanic. Like my mind is flying. It had not occurred to me that the Seroquel could be causing it. I keep wondering what's wrong with me.

You are not going to 'feel' anything regarding mood changes for 6-12 weeks.

I take 300mg at bed time and am out like a light. I take 1-3 25mg as needed during the day if I am having a high anxiety event. They do nothing to make me tired.