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  #401  
Old Apr 03, 2014, 05:02 AM
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Jolisse Jolisse is offline
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Quote:
Originally Posted by punkybrewster6k View Post
Just got back from the big meeting with a room full of doctors for Bean. Starting Clozaril tonight, she is on the federal list for it now.

I cried.

I was hoping they would tell me her problem was from taking so many meds over the years and I was praying that when they flushed all the meds from her body, it would show that she was better now.
(sigh) im upset.


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I work in the healthcare field and have had patients on Clozaril. I can tell you for some people, it's a miracle drug.
Hopefully this med will work for Bean and she will start to feel better.
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  #402  
Old Apr 03, 2014, 06:42 AM
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Good morning everyone. Hope your day is a good one. Its supposed to be warm today around 40. Maybe I can get some outside work done.

For those who are struggling, (((hug))))

Those who are doing pretty good, be thankful.

And those who are just doin'......try to smile

oxox Carpe Diem.
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  #403  
Old Apr 03, 2014, 08:20 AM
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I got a new laptop and I love it. I had been using a desktop because my old laptop kept overheating. It's nice to be able to stay in bed but still be on a computer. I missed that.
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  #404  
Old Apr 03, 2014, 08:20 AM
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Sometimes psychotic Sometimes psychotic is offline
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Originally Posted by blackwhitered View Post
Oh, that's what Abilify was like for me. Severe akathisia. Geodon gave me akathisia at first, but now it's pretty much gone. I can still relax. I just don't want to spend all day in my room for days on end like I normally do. Does that make sense?
Oh ok that's great for me the socialization was about being constantly doing something...it felt pushed beyond my baseline without any meds.
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  #405  
Old Apr 03, 2014, 08:38 AM
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Originally Posted by sunshine1995 View Post
Sometimes, would u mind figuring out what the difference is between latuda and risperdal. Like what nuerotransmitters they work on. I think latuda must work on norepinephrine bc it creates anxiety in me. Just wondering if u wouldn't mind. I looked but didn't totally understand it. I'd appreciate it when u have the time.
Nope neither one of those is reported to bind the norepinephrine receptor unless it was very recently....if you're interested in this kind of thing I'd recommend picking up a copy of stahls essential psychopharmacology it's visually straight forward...pictures with different size receptors on the drug... One of the problems though is you seem to be dealing with newer APs and much less is known abut them....Latuda in that book is pretty much the standard d2 along with a couple of serotonin receptors and minor binding at histamine thus no weight increase....the whole panel was never worked out because it was does so for the older ones simply because they had no idea about the mechanism of action...anyway nothing at all suspicious about latuda's binding profile it may be that it doesn't bind something that normally would calm you down....
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Last edited by Sometimes psychotic; Apr 03, 2014 at 10:55 AM. Reason: typo
  #406  
Old Apr 03, 2014, 09:08 AM
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Erti Erti is offline
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Something to make some of you smile. lol I defiantly need it.

Roll Call 21
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  #407  
Old Apr 03, 2014, 09:42 AM
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Didn't have my second depot today because of the horrendous side effects, phew!
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  #408  
Old Apr 03, 2014, 12:29 PM
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Quote:
Originally Posted by blackwhitered View Post
I'm trying to think of how to describe how I feel, but it's hard to explain.

I think the Geodon is helping with my negative symptoms. Like socialization. I can't remember the last time I felt lonely. I usually don't make an effort to go out or meet people. I had a few friends but unless I was obligated to go somewhere with them, I didn't. Sometimes didn't leave the house for long periods of time. But now on the Geodon, I feel like I actually want to do things... It's weird because it's not something I usually think about. The Geodon doesn't do everything... still having weird/distressing thoughts and some hallucinations... but this is a step. Never thought I would be so excited about being lonely, ha.
I take Geodon and don't ever feel lonely. I've been on it this time around for 7 years and don't think I've ever felt lonely through this length of time.
  #409  
Old Apr 03, 2014, 12:41 PM
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Originally Posted by blackwhitered View Post
The downside of Geodon is that mixed with thorazine, it gives me galactorrhea. And it makes me sooo tired. Like bordering on narcolepsy tired. I have to nap a lot. And sometimes I get dystonia/muscle stiffness. So far it's worth it though.
I also experience muscle stiffness in my legs but more so in my jaw which sometimes can be a challenge when eating or speaking. I've tried Cogentin and Artane but the trade off was greater side effects which caused more problems for me so I don't take anything and just deal with the muscle stiffness. Other than the dystonia Geodon manages my sza well.
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  #410  
Old Apr 03, 2014, 12:59 PM
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Originally Posted by sunshine1995 View Post
Cracking hope ur ok, you never really talk about what's going on with u. But I hope ur ok.
.

I'm okay. I just have a lot going on. Sometimes I don't post if all I have is negative. I don't want to bring anyone down with my mess. I'm just trying to stay as busy as possible in order to keep from dealing with the mess that goes on inside my head. I'm trying very hard to stay positive and just push through. Thanks for thinking of me. Even when I don't post I'm still keeping up with Roll Call. If I get behind it is hard to catch up
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  #411  
Old Apr 03, 2014, 01:03 PM
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  #412  
Old Apr 03, 2014, 01:33 PM
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went to class today. probably made a 100 on the test. we got our grades back in the class so far and im making 100%. 400 out of 400 points. that's awesome!!
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  #413  
Old Apr 03, 2014, 02:07 PM
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Originally Posted by Cracking Slowly View Post
I'm okay. I just have a lot going on. Sometimes I don't post if all I have is negative. I don't want to bring anyone down with my mess. I'm just trying to stay as busy as possible in order to keep from dealing with the mess that goes on inside my head. I'm trying very hard to stay positive and just push through. Thanks for thinking of me. Even when I don't post I'm still keeping up with Roll Call. If I get behind it is hard to catch up
Good...I personally think that it's ok to talk about the negative stuff. Ur usually pretty positive all the time. Very supportive of others, which is great but I think it would be good for u to get it out, what's going with u I mean.
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  #414  
Old Apr 03, 2014, 02:14 PM
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Originally Posted by Sometimes psychotic View Post
Nope neither one of those is reported to bind the norepinephrine receptor unless it was very recently....if you're interested in this kind of thing I'd recommend picking up a copy of stahls essential psychopharmacology it's visually straight forward...pictures with different size receptors on the drug... One of the problems though is you seem to be dealing with newer APs and much less is known abut them....Latuda in that book is pretty much the standard d2 along with a couple of serotonin receptors and minor binding at histamine thus no weight increase....the whole panel was never worked out because it was does so for the older ones simply because they had no idea about the mechanism of action...anyway nothing at all suspicious about latuda's binding profile it may be that it doesn't bind something that normally would calm you down....
Sometimes, first thank u for looking into that for me. So maybe it's bc it doesn't work on histamine....maybe that's what's causing the anxiety. Bc I think risperdal works on histamine. If I understood u correctly, latuda not working on histamine, is what also helps it not be a weight gainer. Right?

What does histamine do btw?
  #415  
Old Apr 03, 2014, 02:15 PM
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Roll Call 21
That's one of my favorite sayings.
  #416  
Old Apr 03, 2014, 02:26 PM
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Originally Posted by sunshine1995 View Post
Sometimes, first thank u for looking into that for me. So maybe it's bc it doesn't work on histamine....maybe that's what's causing the anxiety. Bc I think risperdal works on histamine. If I understood u correctly, latuda not working on histamine, is what also helps it not be a weight gainer. Right?

What does histamine do btw?
Well it does work on histamine a little bit but not as much as the others thus less weight gain...the APs were initially developed as a potent antihistamine and a lot of that structure remains in the whole class so unless taking a standard anti-histamine for your allergies or cold causes you to have anxiety I doubt that's the problem. So what I'm saying is for risperidone we know 20-30 receptors it binds to but for latuda maybe 5? You can't figure out the differences if the studies of the other receptors haven't been done...your drug is too new to answer the question....
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  #417  
Old Apr 03, 2014, 02:31 PM
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Man, sometimes psychotic your so well read about these things. Very impressive can you be my gp you'd do a better job
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  #418  
Old Apr 03, 2014, 02:33 PM
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Man, sometimes psychotic your so well read about these things. Very impressive can you be my gp you'd do a better job
As long as I can diagnosis everyone with psychosis I'd be fine but I know zero outside of that
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  #419  
Old Apr 03, 2014, 02:34 PM
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Originally Posted by Sometimes psychotic View Post
Well it does work on histamine a little bit but not as much as the others thus less weight gain...the APs were initially developed as a potent antihistamine and a lot of that structure remains in the whole class so unless taking a standard anti-histamine for your allergies or cold causes you to have anxiety I doubt that's the problem. So what I'm saying is for risperidone we know 20-30 receptors it binds to but for latuda maybe 5? You can't figure out the differences if the studies of the other receptors haven't been done...your drug is too new to answer the question....
Oh ok, maybe holdol could be a good one to try. I looked up side effects and weight gain doesn't seem to be one one of them.
  #420  
Old Apr 03, 2014, 02:40 PM
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Originally Posted by sunshine1995 View Post
Oh ok, maybe holdol could be a good one to try. I looked up side effects and weight gain doesn't seem to be one one of them.
Haldol definately causes weight gain that is what Newtus is on---comparable to risperidone from what I remember but not as bad as zyprexa. There are only 3 that are weight neutral that I'm aware of....abilify, geodon and latuda...
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  #421  
Old Apr 03, 2014, 02:51 PM
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Haldol definately causes weight gain that is what Newtus is on---comparable to risperidone from what I remember but not as bad as zyprexa. There are only 3 that are weight neutral that I'm aware of....abilify, geodon and latuda...
Yeah I know that's what newtus is on. That's weird bc when I looked it up it didn't say weight gain but I'll take ur word for it.

I've tried geodon, I was on it for 2 months. My psych nurse said u have to eat 750 calories with it, which was a pain to keep up with and it caused severe nausea in me. And if I was late taking it I would vomit. And it didn't really work that we'll, and I was on a high dose.

Still haven't tried ability, I forgot about that one.
  #422  
Old Apr 03, 2014, 02:53 PM
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Weight gain induced by haloperidol, risperidon... [Schizophr Res. 2008] - PubMed - NCBI

So here is a study on haldol, risperidone and zyprexa---these are people receiving initial meds so what happens is people on haldol gain maybe a little less the first 3 months but by the end of a year people on all three meds have gained 20 pounds. So I have seen meta-analysis of haldol suggesting lower weight gain but haldol is not a first line treatment and according to my pdoc you pretty much gain all the weight you're going to in the first year then its stable after that so trials where people have already been on APs for a year really aren't valid for this kind of comparison IMO.
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  #423  
Old Apr 03, 2014, 02:57 PM
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Originally Posted by sunshine1995 View Post
Yeah I know that's what newtus is on. That's weird bc when I looked it up it didn't say weight gain but I'll take ur word for it.

I've tried geodon, I was on it for 2 months. My psych nurse said u have to eat 750 calories with it, which was a pain to keep up with and it caused severe nausea in me. And if I was late taking it I would vomit. And it didn't really work that we'll, and I was on a high dose.

Still haven't tried ability, I forgot about that one.
yeah you're supposed to take both latuda and geodon with food so they both have that drawback-----abilify----that's the one I was on and the main problem seems to be akathasia for most people----I had a minor tremor but no major weight gain or prolactin issues. For some people it just doesn't work well though because it is a weak activator of D2 rather than a blocker but for me it was the best...
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  #424  
Old Apr 03, 2014, 03:13 PM
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T just texted me and told me he is going on vacation. i guess he forgot to tell me in person.

edit: at least he gets back on tuesday
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  #425  
Old Apr 03, 2014, 03:13 PM
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yeah you're supposed to take both latuda and geodon with food so they both have that drawback-----abilify----that's the one I was on and the main problem seems to be akathasia for most people----I had a minor tremor but no major weight gain or prolactin issues. For some people it just doesn't work well though because it is a weak activator of D2 rather than a blocker but for me it was the best...
Well I can take congentin for that. Yeah u have to take geodon and latuda with food but on latuda u only have to eat 350 calories, I can deal with that.

I have a feeling at the end of this med merry go round I'm gonna end up on risperdal...Then what am I gonna do? Just end up even more overweight. This sucks.

I wish I didn't have to take a ap at all. Since that psychosis everything has changed. I get paranoid easier and my cognitive abilities aren't like they were before. I go into mixed states and manias more. The psych nurse said if I can stay stable for a year we can try and go off of them. Damn mental illness.
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