Roll Call 21

I work in the healthcare field and have had patients on Clozaril. I can tell you for some people, it's a miracle drug.
Hopefully this med will work for Bean and she will start to feel better.

Good morning everyone. Hope your day is a good one. Its supposed to be warm today around 40. Maybe I can get some outside work done.

For those who are struggling, (((hug))))

Those who are doing pretty good, be thankful.

And those who are just doin'......try to smile

oxox Carpe Diem.

I got a new laptop and I love it. I had been using a desktop because my old laptop kept overheating. It's nice to be able to stay in bed but still be on a computer. I missed that.

Oh ok that's great for me the socialization was about being constantly doing something...it felt pushed beyond my baseline without any meds.

Nope neither one of those is reported to bind the norepinephrine receptor unless it was very recently....if you're interested in this kind of thing I'd recommend picking up a copy of stahls essential psychopharmacology it's visually straight forward...pictures with different size receptors on the drug... One of the problems though is you seem to be dealing with newer APs and much less is known abut them....Latuda in that book is pretty much the standard d2 along with a couple of serotonin receptors and minor binding at histamine thus no weight increase....the whole panel was never worked out because it was does so for the older ones simply because they had no idea about the mechanism of action...anyway nothing at all suspicious about latuda's binding profile it may be that it doesn't bind something that normally would calm you down....

Something to make some of you smile. lol I defiantly need it.

Didn't have my second depot today because of the horrendous side effects, phew!

I take Geodon and don't ever feel lonely. I've been on it this time around for 7 years and don't think I've ever felt lonely through this length of time.

I also experience muscle stiffness in my legs but more so in my jaw which sometimes can be a challenge when eating or speaking. I've tried Cogentin and Artane but the trade off was greater side effects which caused more problems for me so I don't take anything and just deal with the muscle stiffness. Other than the dystonia Geodon manages my sza well.

I'm okay. I just have a lot going on. Sometimes I don't post if all I have is negative. I don't want to bring anyone down with my mess. I'm just trying to stay as busy as possible in order to keep from dealing with the mess that goes on inside my head. I'm trying very hard to stay positive and just push through. Thanks for thinking of me. Even when I don't post I'm still keeping up with Roll Call. If I get behind it is hard to catch up

went to class today. probably made a 100 on the test. we got our grades back in the class so far and im making 100%. 400 out of 400 points. that's awesome!!

Good...I personally think that it's ok to talk about the negative stuff. Ur usually pretty positive all the time. Very supportive of others, which is great but I think it would be good for u to get it out, what's going with u I mean.

Sometimes, first thank u for looking into that for me. So maybe it's bc it doesn't work on histamine....maybe that's what's causing the anxiety. Bc I think risperdal works on histamine. If I understood u correctly, latuda not working on histamine, is what also helps it not be a weight gainer. Right?

What does histamine do btw?

That's one of my favorite sayings.

Well it does work on histamine a little bit but not as much as the others thus less weight gain...the APs were initially developed as a potent antihistamine and a lot of that structure remains in the whole class so unless taking a standard anti-histamine for your allergies or cold causes you to have anxiety I doubt that's the problem. So what I'm saying is for risperidone we know 20-30 receptors it binds to but for latuda maybe 5? You can't figure out the differences if the studies of the other receptors haven't been done...your drug is too new to answer the question....

Man, sometimes psychotic your so well read about these things. Very impressive can you be my gp you'd do a better job

As long as I can diagnosis everyone with psychosis I'd be fine but I know zero outside of that

Oh ok, maybe holdol could be a good one to try. I looked up side effects and weight gain doesn't seem to be one one of them.

Haldol definately causes weight gain that is what Newtus is on---comparable to risperidone from what I remember but not as bad as zyprexa. There are only 3 that are weight neutral that I'm aware of....abilify, geodon and latuda...

Yeah I know that's what newtus is on. That's weird bc when I looked it up it didn't say weight gain but I'll take ur word for it.

I've tried geodon, I was on it for 2 months. My psych nurse said u have to eat 750 calories with it, which was a pain to keep up with and it caused severe nausea in me. And if I was late taking it I would vomit. And it didn't really work that we'll, and I was on a high dose.

Still haven't tried ability, I forgot about that one.

Weight gain induced by haloperidol, risperidon... [Schizophr Res. 2008] - PubMed - NCBI

So here is a study on haldol, risperidone and zyprexa---these are people receiving initial meds so what happens is people on haldol gain maybe a little less the first 3 months but by the end of a year people on all three meds have gained 20 pounds. So I have seen meta-analysis of haldol suggesting lower weight gain but haldol is not a first line treatment and according to my pdoc you pretty much gain all the weight you're going to in the first year then its stable after that so trials where people have already been on APs for a year really aren't valid for this kind of comparison IMO.

yeah you're supposed to take both latuda and geodon with food so they both have that drawback-----abilify----that's the one I was on and the main problem seems to be akathasia for most people----I had a minor tremor but no major weight gain or prolactin issues. For some people it just doesn't work well though because it is a weak activator of D2 rather than a blocker but for me it was the best...

T just texted me and told me he is going on vacation. i guess he forgot to tell me in person.

edit: at least he gets back on tuesday

Well I can take congentin for that. Yeah u have to take geodon and latuda with food but on latuda u only have to eat 350 calories, I can deal with that.

I have a feeling at the end of this med merry go round I'm gonna end up on risperdal...Then what am I gonna do? Just end up even more overweight. This sucks.

I wish I didn't have to take a ap at all. Since that psychosis everything has changed. I get paranoid easier and my cognitive abilities aren't like they were before. I go into mixed states and manias more. The psych nurse said if I can stay stable for a year we can try and go off of them. Damn mental illness.