Roll Call 24

So honestly I'd pick another topic unless you want to do something incredibly vague with hundreds of potential genes. We went through a lot of this when a couple of us got our genome sequenced---there are some snps about 185-186 that are common so they are on chips where you can get your sequence at that snp but there also seem to be a lot of de novo mutations---rare variants----so here is a link to us talking about the outcome of our genomes some of the genes and their phenotypes are in there starting around page 31 and beyond

https://forums.psychcentral.com/schi...l-news-31.html

Basically you can have any one of these mutations and be fine or develop sz its just your tendency increases with more of these mutations....some are quite common though where like 50% of the population will have a mutation. The large GWAS studies I talk about the latest results here....

http://forums.psychcentral.com/schiz...-genetics.html

So its not any single mutation----its actually been described as a pathway disorder so a mutation of any of the proteins in a signaling pathway will have the same outcome as far as phenotype.

Even with clear sz risk factors like disc----there is the issue that it appears to increase risk for a psychiatric condition which could be bipolar or depression and not just sz----if they take those proteins and knock them out in a mouse it actually generates an autism phenotype instead.

So the long and short of it is there is no mutation which guarantees a sz phenotype----everybody has a different mutation and you also need a stressor or developmental progression to trigger the disease. For the developmental aspect its been proposed that neural pruning is somehow misregulated leading to issues in neuron connectivity.

slow day

Tru dat. Seeing a couple of friends on Facebook graduate college and I find myself jelous of them lol.

thats how i felt Erti. i just let college pass me by. i wish i hadnt now but i had troubles with my mental health in college. now im on disability. never thought id be like this at this age - on disability and all

Yeah we're at that age where our high school friends are finishing up their bachelors in college and doing things with their lives. I'm sitting at home collecting SSI and doing nothing with my life. **** mental illness.

EXACTLY. thats how what im thinking. sitting at home. collecting disability. doin nothing. its self esteem ruining. idk what to even to do with my time.

so i failed one of my classes. im mad. and sad. im a loser. i hate myself. i should give up on school. i made an A in the other one. but who cares cuz i failed the other one. god. its all my fault. feeling bad. ugh. ****. wtf. i missed 5 assignments because i was psychotic. why cant i just be normal. whatever

junkdna

Yeah. We need some sort of hobby or something. At least that's what my stepdads mom tells me. My ex boyfriend keeps telling me to go back to school. Thing is... I don't know what to do with my life. I just want to be happy with myself. You're right it's self esteem ruining. Soul sucking.

At least you're trying. I admire you for that.

the thing is what hobby? ive been through so many hobbies. and im just not happy with them. my dad tells me to go back to school. but idk. i dont think i can keep up with school.

I have no idea. I don't find anything exciting as a hobby.

i keep feelig attached to this old therapist. ugh someone help me
i feel like i should go bak and say im sorry idk idk idk...

why wont this paranoia go away

Could you just mail her a card or something...I'm not sure it's good for you to see her again...it will just make it harder to separate...

I feel exactly the same everyone around me has been to university and I'm just collecting benefits like a nobody. The worst thing is part of me doesn't even care though

your right i shouldnt go. i just need a way to mentally seperate myself from her. idk how tho.

Hopefully the relationship you start with your new T will help...substitution is pretty effective...in fact that's the point of the whole thing anyway...
It's supposed to sort of get you to think about what you need in life and eventually find someone who can fill all of your needs where as the T will not always be there for you.

My mother told me that My Fiance' got into a fight with this guy who punched him in the nose now they are holding them both in a jail cell not together thankfully they are in different cells...and I am so worried about him I don't want him to be in trouble he's not the one who started the fight.His nose was bleeding and he has a slight concussion And I can't call him and talk to him and I can't go see him right now and it makes me so sick to my stomach I hope he'll be ok I am so worried right now. I can't be on here for much longer I think they are going to be shutting off the computer area around 9 tonight. I just wanted to say Hi. I feel horrible right now... I will let you all know how everything's going tomorrow when I can get back online.

Anybody on?

i need to not look at the "Romantic Feelings for my T" forum. it is so triggering. i get angry taht people think its a good idea to be romantic with a T. i want to shake them and tell them ive been there and it sucks. but of course they wouldnt believe me. because they feel special and loved. well i felt special and loved too and look what happened to me. its all predators just grooming their prey. ugh. i hate that forum

ive been up for awhile. i feel really paranoid and anxious. i feel like cutting. very paranoid. i wish more people were on here today.

today for the first time ever i broke the news to my dad only that i been on an online support group for 4-5 years

is ur dad off of work today newtus?

im off today. not feeling as bad as i was yesterday. i am still ashamed of my grade tho. it will disappoint my mom. i told T about it. we texted a lot this morning.he said i should make "wwTstm" bracelets (what would T say to me) because i told him that ive internalized a lot of the things he says to me and find it easier to say it to myself and believe it.

That's interesting...I don't really mention it to anyone either...not for any reason but I rarely talk about being sick anymore to anyone irl....

What did he say about it?